Results 181 to 190 of about 41,691 (265)

Quercetin Inhibits Orthodontic Tooth Movement‐Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL‐17/Hippo/YAP Axis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Orthodontic tooth movement (OTM) is frequently accompanied by inflammatory responses, including periodontitis, which may compromise treatment outcomes. This study investigated the protective role of quercetin, a natural flavonoid, in OTM‐associated periodontitis and its underlying mechanism involving macrophage metabolic ...
Fen Yao, Zhiping Song, Wuchao Wu, Bingqian Liu, Rongqi Xia, Yao Zhou, Wenxia Wang, Yujie Chen, Zhengyu Liao   +8 more
wiley   +1 more source

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

RANKL inhibition in bone metastases

Folia Pharmacologica Japonica, 2013
openaire   +3 more sources

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging. It is correlated with an increased risk of falls, fractures, disability, and mortality.
Javeria Taj, Rabia Zafar, Joshua Ekouo, Ayesha Junaid, Dujardin Makeda, Kinza Latif, Hermann Yokolo   +6 more
wiley   +1 more source

Role of Caffeine and Ethanol in Modulating Expression of Receptor Activator of Nuclear Factor κβ (RANK) and Osteoprotegerin (OPG) during Orthodontic Tooth Movement: An In Vivo Study. [PDF]

Acta Med Philipp
Pawinru AS, Erwansyah E, Habar EH, Fauzi A, Aminullah, Gayatri G, Puspitasari Y, Alwi IP, Hasanah AH.   +8 more
europepmc   +1 more source

Expanding the Phenotype of TAB2‐Related Syndrome: The First Case With Cleft Palate and Insights Into Palatal Development

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1427-1430, June 2026.
Alberto De Rosa, Silvia Kalantari, Marta Carboni, Antonella Casella, Elisa Giorgio, Antonia Apicella, Alessia Claudia Codazzi, Fabio Sirchia   +7 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

The Presence of SFRP1 Reduces the High Risk of Metastasis in RANKL-Expressing Canine Mammary Cancers. [PDF]

Animals (Basel)
Durys N, Morris JS, Klopfleisch R, Stein T.   +3 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Porphyromonas gingivalis lipids enhance RANKL-mediated osteoclast formation. [PDF]

Bone
Zambrello MA, Sanjay A, Rahmlow A, Chen L, Etoh N, Lamm E, Sobue T, Uddaraju K, Clark RB, Rowe DW, Nichols FC.   +10 more
europepmc   +1 more source