Results 171 to 180 of about 41,691 (265)

Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
ABSTRACT Bone tissue regeneration is a complex physiological process dependent on the spatiotemporal coordination of immune cells and stem cells. Conventional research primarily elucidates the mechanism through which materials facilitate bone formation by initially modulating macrophages and subsequently encouraging the osteogenic differentiation of ...
Yang Lu, Kun Su, Daqian Liu, Chunyu Liu, Muyan Qin, Shuaijie Li, Pengfei Tian, Yansong Wang, Yingbo Wang, Lei Chu, Xu Cui, Haobo Pan   +11 more
wiley   +1 more source

Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK-NFATc1 Signaling. [PDF]

Curr Issues Mol Biol
Zhang L, Tabandeh M, Deepak V.
europepmc   +1 more source

Osteocytes, RANKL and bone loss [PDF]

Nature Reviews Endocrinology, 2011
openaire   +2 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Transcriptomic profiling and RANKL/RANK/OPG-mediated osteoclastogenesis in zebrafish larvae under simulated microgravity conditions. [PDF]

Front Cell Dev Biol
Carvajal-Agudelo JD, Franz-Odendaal TA.
europepmc   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1318-1326, June 2026.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Development of a Risk Prediction Model for Bone Metastasis in Lung Adenocarcinoma With a T1 Primary Tumor Based on Intratumoral and Peritumoral Radiomics

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Purpose Bone metastasis significantly affects the prognosis of lung adenocarcinoma (LUAD) patients. This study aims to construct and validate a risk prediction model for bone metastasis in LUAD with a T1 primary tumor based on intratumoral and peritumoral radiomics features.
Ting Li, Hui Zheng, Yang Guo, Kemeng Zhang, Meiyan Liao   +4 more
wiley   +1 more source

Function of soluble RANKL deciphered [PDF]

Nature Reviews Endocrinology, 2019
openaire   +2 more sources