Results 21 to 30 of about 105,143 (344)

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts [PDF]

Royal Society Open Science, 2019
Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for new medicines that modulate the formation and function of osteoclasts is a potential approach for treating osteoclast-related bone diseases.
Liuliu Yan, Lulu Lu, Fangbin Hu, Dattatrya Shetti, Kun Wei   +4 more
doaj   +1 more source

RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss

EMBO Reports, 2021
Receptor activator of NF‐κB ligand (RANKL) is essential for osteoclast formation and bone remodeling. Nevertheless, the cellular source of RANKL for osteoclastogenesis has not been fully uncovered.
Yan Hu, Xiaoqun Li, Xin Zhi, Wei Cong, Biaotong Huang, Huiwen Chen, Yajun Wang, Yinghua Li, Lipeng Wang, C. Fang, Jiawei Guo, Ying Liu, J. Cui, Liehu Cao, W. Weng, Qirong Zhou, Sicheng Wang, Xiao Chen, Jiacan Su   +18 more
semanticscholar   +1 more source

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

Molecules, 2020
Receptor activator of nuclear factor-κB ligand (RANKL) is a cytokine responsible for bone resorption. It binds its receptor RANK, which activates osteoporosis.
Małgorzata Zakłos-Szyda, Grażyna Budryn, Joanna Grzelczyk, Horacio Pérez-Sánchez, Dorota Żyżelewicz   +4 more
doaj   +1 more source

Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis

Nature Communications, 2022
One of the major challenges for discovering protein-protein interaction inhibitors is identifying selective and druggable binding sites at the protein surface.
Dane Huang, Chao Zhao, Ruyue Li, Bingyi Chen, Yuting Zhang, Zhejun Sun, Junkang Wei, Huihao Zhou, Qiong Gu, Jun Xu   +9 more
semanticscholar   +1 more source

Research progress on the relationship between osteocytes and periodontitis

口腔疾病防治, 2020
Osteocytes, which develop from osteoblasts, are recognized as the main cells embedded in mature bone tissue. The traditional notion is that osteocytes exclusively play a structural role, however, with the development of related research in recent years ...
ZHU Xuanzhi, MA Rui, XIE Xudong, WANG Jun   +3 more
doaj   +1 more source

Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling

BMC Immunology, 2021
Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei, Linda T. Senbanjo, H. Aljohani, Therwa Hamza, M. Chellaiah   +4 more
semanticscholar   +1 more source

The Effects of Acute Exercise on RANKL/RANK/OPG Pathway and Bone Metabolic Markers in Healthy College Female [PDF]

운동과학, 2018
PURPOSE The purpose of this study was to examine the effects of acute exercise with difference Intensitis on RANKL/RANK/OPG pathway and bone metabolic markers in healthy college female. METHODS Ten healthy college females (aged 21.5±1.84 years; VO2max 37.
Ji-Yeon Kim, Hyo-Jin Kim, Dong-Ho Park, Yun-A Shin, Seok-Ki Min, Chang-Sun Kim   +5 more
doaj   +1 more source

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

BioMed Research International, 2020
Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world.
Mohammad Tobeiha, M. Moghadasian, Negin Amin, S. Jafarnejad   +3 more
semanticscholar   +1 more source

Medienkompetenzvermittlung im Fachgegenstand Musikerziehung

Medienimpulse, 2014
Dieser Artikel befasst sich mit der Integration von Medienbildung in den Musikunterricht und behandelt Aspekte inwieweit musikerzieherische Inhalte auch zur Medienbildung beitragen können.
Martin Rankl
doaj   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources