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ПАТОФИЗИОЛОГИЧЕСКАЯ РОЛЬ ОСТЕОПРОТЕГЕРИНА ПРИ АТЕРОСКЛЕРОЗЕ И САХАРНОМ ДИАБЕТЕ
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2022 Сахарный диабет справедливо называют неинфекционной эпидемией 21 века. Вместе с тем сердечно-сосудистые заболевания по-прежнему лидируют среди причин смертности в мире.
A. R. Obukhovich, N. N. Iaskevich
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Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]
, 2010 Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja +5 more
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Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]
, 2017 Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S +5 more
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International Journal of Nanomedicine, 2023 Lin Liu, Haifeng Tang, Yanjun Wang Department of Emergency, Honghui Hospital of Xi’an Jiaotong University, Xi’an, 710054, People’s Republic of ChinaCorrespondence: Yanjun Wang; Haifeng Tang, Department of Emergency, Honghui Hospital of Xi’an Jiaotong ...
Liu L, Tang H, Wang Y
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Targeting RANKL in metastasis [PDF]
BoneKEy Reports, 2014 Acting through its cognate receptor, receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) is an essential mediator of osteoclast function and survival. Preclinical data have now firmly established that blockade of tumor-induced osteoclastogenesis by RANKL inhibition will not only protect against bone destruction but will also inhibit the
Dougall, W.C. +2 more
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]
, 2017 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran +15 more
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Gerontology, 2015 Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL
Vanja, Nagy, Josef M, Penninger
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Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]
, 2014 Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B +6 more
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A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. [PDF]
, 2007 Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signaling and thus inhibits osteogenesis.
Angela Smolarz +9 more
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Annals of Glaciology, 2016 Snow cover and glaciers in the Karakoram region are important freshwater resources for many down-river communities as they provide water for irrigation and hydropower.
Melanie Rankl, Matthias Braun
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