RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass.
Journal of Clinical Investigation, 2019 Receptor activator of Nfkb ligand (RANKL) activates, while osteoprotegerin (OPG) inhibits, osteoclastogenesis. In turn a neutralizing Ab against RANKL, denosumab improves bone strength in osteoporosis. OPG also improves muscle strength in mouse models of
N. Bonnet +4 more
semanticscholar +1 more source
Changes in Bone Metabolism and Structure in Primary Hyperparathyroidism
Acta Medica Bulgarica, 2020 Parathyroid hormone (PTH) is a key regulator of bone turnover. Depending on the duration of action, the hormone causes catabolic and anabolic effects by binding with specific receptors (PTHR1) in the bone.
Yankova I., Shinkov A., Kovatcheva R.
doaj +1 more source
RANKL inhibits activation of hepatic stellate cells during hepatic fibrosis in mice
陆军军医大学学报, 2023 Objective To explore the biological role of receptor activator of nuclear factor kappa-B ligand (RANKL) in the activation of hepatic stellate cells (HSCs) and the process of hepatic fibrosis.
ZHOU Lijia +4 more
doaj +1 more source
Investigation of the SH3BP2 Gene Mutation in Cherubism [PDF]
, 2008 Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients.
Ahn, Sang-Gun +5 more
core +1 more source
Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
JCI Insight, 2020 In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments.
Ha-Neui Kim +13 more
semanticscholar +1 more source
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]
, 2010 DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E +11 more
core +3 more sources
Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]
, 2019 Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam +6 more
core +2 more sources
TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation
Frontiers in Immunology, 2019 Osteoimmunology peeks into the interaction of bone and the immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown to regulate bone resorption through the expression of RANKL in physiologic and pathologic conditions.
Aseel Marahleh +9 more
semanticscholar +1 more source
Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy
Frontiers in Cell and Developmental Biology, 2020 Osteoporosis is age-related deterioration in bone mass and micro-architecture. Denosumab is a novel human monoclonal antibody for osteoporosis. It is a receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, which binds to and inhibits ...
Ning Zhang +5 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2019 Cartilage and the bordering subchondral bone form a functionally active regulatory interface with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK signaling systems, as key mediators, interact in subchondral bone remodeling ...
B. Kovács, Enikő Vajda, E. Nagy
semanticscholar +1 more source