RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
Biomolecules, 2021 RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellular ...
Que N. Van +5 more
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Compartmentalization of Ras proteins [PDF]
Journal of Cell Science, 2001 ABSTRACT The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms
Prior, I. A., Hancock, J. F.
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The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways. [PDF]
PLoS ONE, 2011 Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini.
Clara L Oeste +10 more
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Nanoclustering as a dominant feature of plasma membrane organization [PDF]
, 2014 Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane ...
Cambi, Alessandra +4 more
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Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]
, 1989 Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A. +5 more
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Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins [PDF]
, 1995 We have identified a gene, SHR5, in a screen for extragenic suppressors of the hyperactive RAS2Val-19 mutation in the budding yeast Saccharomyces cerevisiae. SHR5 was cloned, sequenced, and found to encode a 23-kDa protein not significantly homologous to
Jung, V. +4 more
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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway [PDF]
, 2000 Ras proteins must be localized to the inner surface of the plasma membrane to be biologically active. The motifs that effect Ras plasma membrane targeting consist of a C-terminal CAAX motif plus a second signal comprising palmitoylation of adjacent ...
Apolloni, A. +4 more
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The Role and Function of Ras-association domain family in Cancer: A Review
Genes and Diseases, 2019 Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP.
Mohammad Reza Zinatizadeh +7 more
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Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis [PDF]
, 2010 Ras proteins regulate cell growth, death, and differentiation, and it is well established that this functional versatility is accomplished through their different subcellular localizations.
Ang +38 more
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Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
European Journal of Cell Biology, 2023 The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane.
Ganesh babu Manoharan +3 more
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