The Role and Function of Ras-association domain family in Cancer: A Review
Genes and Diseases, 2019 Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP.
Mohammad Reza Zinatizadeh +7 more
doaj +1 more source
Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
European Journal of Cell Biology, 2023 The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane.
Ganesh babu Manoharan +3 more
doaj +1 more source
Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis [PDF]
, 2010 Ras proteins regulate cell growth, death, and differentiation, and it is well established that this functional versatility is accomplished through their different subcellular localizations.
Ang +38 more
core +1 more source
Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease [PDF]
, 2014 R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases.
Alarcón, Balbino +7 more
core +3 more sources
Dissecting the different biological effects of oncogenic Ras isoforms in cancer cell lines: could stimulation of oxidative stress be the one more weapon of H-Ras? Regulation of oxidative stress and Ras biological effects [PDF]
, 2012 Ras proteins are small GTPase functioning as molecular switches that, in response to particular extracellular signalling, as growth factors, activate a diverse array of intracellular effector cascades regulating cell proliferation, differentiation and ...
BELLAVIA, Maurizio +6 more
core +1 more source
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation [PDF]
, 1996 Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation.
Chrzanowska-Wodnicka, M. +7 more
core +3 more sources
Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
doaj +1 more source
Regulation of Ras Signaling by S-Nitrosylation
Antioxidants, 2023 Ras are a family of small GTPases that function as signal transduction mediators and are involved in cell proliferation, migration, differentiation and survival.
Sónia Simão +3 more
doaj +1 more source
K-Ras protein as a drug target [PDF]
, 2016 K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one million cancer cases/year. In cancers driven by mutant K-Ras, the protein is locked in the active, GTP-bound state constitutively, through a defect in the off ...
Frank McCormick
core +2 more sources
Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators
Acta Pharmaceutica Sinica B, 2021 RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the ...
Yuran Qiu +10 more
doaj +1 more source