Results 101 to 110 of about 45,973 (207)

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source

Development of eNA Sampling for Early Detection of Pathogens in On‐Farm Water Sources

Environmental DNA, Volume 8, Issue 2, March/April 2026.
We compare four water‐sampling methods for detecting microbial and viral eNA in livestock troughs and show all approaches effectively recover community profiles, supporting flexible, field‐ready surveillance of livestock pathogens. ABSTRACT Early detection of livestock pathogens is critical for mitigating risk and implementing timely control or ...
Maxine P. Piggott, Allyson Malpartida
wiley   +1 more source

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors

Scientific Reports
The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without validation of ...
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez   +5 more
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II

Frontiers in Microbiology, 2018
Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome.
Keita Ozaki, Keita Ozaki, Yuki Matsushima, Koo Nagasawa, Takumi Motoya, Akihide Ryo, Makoto Kuroda, Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura   +9 more
doaj   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus. [PDF]

, 2010
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Hasiów-Jaroszewska, B., Kuzniar, A., Leunissen, J.A.M., Peters, S.A., Pospieszny, H.   +4 more
core   +1 more source

A non-canonical RNA silencing pathway promotes mRNA degradation in basal fungi [PDF]

, 2015
The increasing knowledge on the functional relevance of endogenous small RNAs (esRNAs) as riboregulators has stimulated the identification and characterization of these molecules in numerous eukaryotes.
A Dereeper, A Fire, A Gutierrez, A Velayos, AC Franken, Ana Vila, D Cifuentes, E Kiyota, F Hillmann, FE Nicolas, FE Nicolas, FE Nicolas, FE Nicolás, FE Nicolás, Francisco E. Nicolás, Geraldine Butler, H Lange, HC Lee, I Fierro-Monti, I Pócsi, IJ MacRae, J Sambrook, JE Stajich, JP de Haro, K Prufer, K Sorefan, LY Geer, M Cervantes, M Chayakulkeeree, M Ghildiyal, M Ha, M Thran, MD Quiles-Rosillo, N Akimitsu, NG Bologna, O Voinnet, P Comella, PU Christensen, R Aryal, R Parker, RC Edgar, Rosa M. Ruiz-Vázquez, S Calo, S Calo, S Cheloufi, S Gazzani, S Guindon, Santiago Torres-Martínez, SEJ Fischer, Silvia Calo, Simon Moxon, SS Chang, Tamas Dalmay, Trung Anh Trieu, V Garre, Victoriano Garre, W Hansberg, W Sun, Z Luo   +58 more
core   +3 more sources

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source