Results 101 to 110 of about 2,150 (202)

Water Soluble Thermoresponsive Single‐Chain Cyclized/Knotted Polymers from Intramolecular Cyclization Dominated Homopolymerization of PEG Diacrylate

Macromolecular Rapid Communications, EarlyView.
A series of water‐soluble, PEG‐based single‐chain cyclized/knotted polymers are successfully synthesized via the homopolymerization of PEGDA (Mn = 575 and 700 g mol⁻¹, respectively), facilitated by enhanced intramolecular cyclization. These cyclized polymers feature a high cyclization ratio and possess numerous pendant vinyl groups, providing excellent
Zishan Li, Jing Lyu, Yinghao Li, Rijian Song, Chunyu Zhao, Melissa Johnson, Tianyu Mao, Hongyun Tai, Wenxin Wang   +8 more
wiley   +1 more source

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors

Scientific Reports
The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without validation of ...
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez   +5 more
doaj   +1 more source

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Scientific Reports, 2018
Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the ...
Salvatore Ferla, Natalie E. Netzler, Sebastiano Ferla, Sofia Veronese, Daniel Enosi Tuipulotu, Salvatore Guccione, Andrea Brancale, Peter A. White, Marcella Bassetto   +8 more
doaj   +1 more source

The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

BMC Bioinformatics, 2005
Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Dutartre Hélène, Bussetta Cécile, Ferron François, Canard Bruno   +3 more
doaj   +1 more source

Genomic characterization of a RdRp-recombinat nebovirus strain with a novel VP1 genotype

Virus Research, 2018
Nebovirus is a new genus within the family Caliciviridae and is a causative agent of calf diarrhea. The limited nebovirus genomic sequences that are currently available has hampered understanding of nebovirus genetic evolution. The aim of the present study was to determine the genomic characterization of strain Bo/LZB-1/17/CH, which was previously ...
Bin Zhang, Zijing Guo, Cheng Tang, Hua Yue, Qifu He   +4 more
openaire   +3 more sources

Bio‐Inspired, Zwitterionic Copolymers with Amphiphilic Character

Macromolecular Rapid Communications, EarlyView.
Zwitterionic copolymers based on arginine‐derived monomers are produced by xanthate‐supported photo‐iniferter reversible‐addition‐fragmentation chain‐transfer polymerization. Experiments in relevant conditions show that the designed (co)polymers hardly interact with biologically relevant proteins and enzymes such as bovine serum albumine (BSA), fetal ...
Theresa M. Lutz, Cevin P. Braksch, Jonas De Breuck, Matthias Hartlieb, Meike N. Leiske   +4 more
wiley   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

PLoS Pathogens, 2016
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5).
Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa   +15 more
doaj   +1 more source

Thermo‐Responsive Polymer‐Based Nanoparticles: From Chemical Design to Advanced Applications

Macromolecular Rapid Communications, EarlyView.
This work explores the chemical design and applications of thermo‐responsive polymer‐based nanoparticles. Focusing on PNIPAM and POEGMA block copolymers, it highlights their thermo‐responsive behaviors and advanced functionalities in imaging, drug delivery, and cell proliferation studies.
Giuseppe Nunziata, Marco Nava, Elisa Lacroce, Fabio Pizzetti, Filippo Rossi   +4 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source