Results 11 to 20 of about 45,973 (207)
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]
PLoS Pathogens, 2015 For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter +11 more
doaj +4 more sources
RdRp or RT, That is the Question [PDF]
Molecular Biology and Evolution, 2021 Abstract The RNA-dependent RNA polymerase (RdRp) of all known double-stranded RNA viruses is located within the viral particle and is responsible for the transcription and replication of the viral genome. Through an RT-PCR assay, we determined that purified virions, in vitro translated RdRp proteins, and purified recombinant RdRp ...
Mahtab Peyambari +2 more
openaire +2 more sources
Snapshots of a Non-Canonical RdRP in Action [PDF]
Viruses, 2021 RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polymerization activity.
Diego S. Ferrero +2 more
openaire +5 more sources
Exploring RdRp–remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV [PDF]
SAR and QSAR in Environmental Research, 2020 A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has resulted in an increasing number of patients globally, and has become a highly lethal pathogenic member of the coronavirus family affecting humans. 2019-nCoV has established itself as one of the most threatening pandemics that human beings have faced, and therefore analysis and ...
Singh, P.K., Pathania, S., Rawal, R.K.
openaire +2 more sources
Experimental Gerontology, 2021 RT-qPCR is the most reliable molecular method for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed results of RT-qPCR obtained for 3044 patients diagnosed as SARS-CoV-2-positive using four different molecular tests utilizing five RNA sequences.
Mikuła-Pietrasik, Justyna +1 more
openaire +2 more sources
Rapidly self-deoxygenating controlled radical polymerization in water via in situ disproportionation of Cu(i) [PDF]
, 2020 Rapidly self-deoxygenating Cu-RDRP in aqueous media is investigated. The disproportionation of Cu(I)/Me6Tren in water towards Cu(II) and highly reactive Cu(0) leads to O2-free reaction environments within the first seconds of the reaction, even when the ...
Haddleton, David M. +4 more
core +1 more source
Deep Sequencing Analysis of RNAs from Citrus Plants Grown in a Citrus Sudden Death-Affected Area Reveals Diverse Known and Putative Novel Viruses. [PDF]
, 2017 Citrus sudden death (CSD) has caused the death of approximately four million orange trees in a very important citrus region in Brazil. Although its etiology is still not completely clear, symptoms and distribution of affected plants indicate a viral ...
Coletta-Filho, Helvecio D +7 more
core +7 more sources
Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
ACS Omega, 2023 Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegylated interferon-α and ribavirin are the only antiviral agents available for the treatment of chronic patients.
Preeti Hooda +4 more
openaire +3 more sources
Journal of Pure and Applied Microbiology, 2020 COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and MERS it’s structural and sequence similarity has abled ...
Hiran Kanti Santra, Debdulal Banerjee
doaj +1 more source
Frontiers in Immunology, 2022 SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the coronavirus family, appeared in 2019 and has caused the largest global public health and economic emergency in recent history, affecting almost all sectors of society. SARS-CoV-
Xiaoming Bai +11 more
doaj +1 more source