SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
Biomedicines, 2021 The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), urgently needs effective prophylactic and therapeutic drugs. RNA-dependent RNA polymerase (RdRp), essential for replicating and transcribing a viral RNA genome,
Jung Sun Min, Sunoh Kwon, Young-Hee Jin
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In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis [PDF]
International Journal of Molecular Sciences, 2023 Norovirus (HNoV) is a leading cause of gastroenteritis globally, and there are currently no treatment options or vaccines available to combat it. RNA-dependent RNA polymerase (RdRp), one of the viral proteins that direct viral replication, is a feasible ...
Rami J. Obaid +10 more
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Plant-Derived Natural Polyphenols as Potential Antiviral Drugs Against SARS-CoV-2 via RNA‐dependent RNA Polymerase (RdRp) Inhibition: An In-Silico Analysis [PDF]
Journal of Biomolecular Structure and Dynamics, 2020 The sudden outburst of Coronavirus disease (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a massive threat to global public health. Currently, no therapeutic drug or vaccine exists to treat COVID-19.
Satyam Singh +2 more
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Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2 [PDF]
Biomedicines, 2022 The natural plant dietary polyphenols 1,2,3,4,6-O-Pentagalloylglucose (PGG) and proanthocyanidin (PAC) have potent antioxidant activity and a variety of pharmacological activities, including antiviral activity.
Young-Hee Jin +5 more
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Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge [PDF]
Molecules, 2020 The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism.
Francesca Picarazzi +4 more
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Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43 [PDF]
Scientific Reports, 2022 Fatty acids belong to a group of compounds already acknowledged for their broad antiviral efficacy. However, little is yet known about their effect on replication of human coronaviruses.
Anna Goc +3 more
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Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
Molecular Biology and Evolution, 2022 RNA viruses are abundant, highly diverse, and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of RNA virus species have been catalogued.
I. Olendraite, Katherine Brown, A. Firth
semanticscholar +3 more sources
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]
PLoS Pathogens, 2015 For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter +11 more
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RdRp mutations are associated with SARS-CoV-2 genome evolution
PeerJ, 2020 COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral ...
Doğa Eskier +3 more
semanticscholar +5 more sources
Exploring Erythrina flavonoids as potential SARS-CoV-2 RdRp inhibitors through virtual screening, in silico ADMET evaluation, and molecular dynamics simulation studies [PDF]
Scientific ReportsThe COVID-19 pandemic, caused by SARS-CoV-2, has intensified the search for effective antiviral agents. This study investigates the inhibitory potential of 473 flavonoids from the genus Erythrina against the key enzyme of SARS-CoV-2, RNA-dependent RNA ...
Tati Herlina +6 more
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