Results 11 to 20 of about 2,150 (202)

Triple targeting of human IMPDH, SARS-CoV-2 RdRp, and Rhizopus oryzae RdRp: An in silico perspective

Journal of King Saud University - Science, 2023
Objectives: Mucormycosis has been reported associated with SARS-CoV-2 infections during the last year. The viral RNA-dependent RNA polymerase (RdRp) was proved to be a critical protein target in viral and fungal pathogens. The human inosine monophosphate dehydrogenase (IMPDH) is an evolved antiviral and antimicrobial therapeutic target.
Abdel-moniem S. Hassan, Abdo A. Elfiky, Alaa M. Elgohary   +2 more
openaire   +2 more sources

Repurposed drug molecules targeting NSP12 protein of SARS-CoV-2: An in-silico study

AIMS Molecular Science, 2023
The emergence of SARS-CoV-2 created a havoc worldwide, causing high morbidity, serious complications and mortality. The ORF1ab of SARS-CoV-2 has 16 non-structural proteins which are required for genome replication and transcription.
Bhawna Sharma , Bennet Angel, Vankadoth Umakanth Naik, Annette Angel, Vinod Joshi , BM Shareef, Neha Singh, Ambreen Shafaat Khan, Poorna Khaneja, Shilpa Barthwal, Ramesh Joshi , Nuzhat Maqbool Peer , Kiran Yadav , Komal Tomar, Satendra Pal Singh   +14 more
doaj   +1 more source

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors

ACS Omega, 2023
Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegylated interferon-α and ribavirin are the only antiviral agents available for the treatment of chronic patients.
Preeti Hooda, Mohammed Al-Dosari, Neha Sinha, Mohammad K. Parvez, Deepak Sehgal   +4 more
openaire   +3 more sources

COVID‐19 and myasthenia gravis: A review of neurological implications of the SARS‐COV‐2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Introduction This review highlights the potential mechanisms of neuromuscular manifestation of COVID‐19, especially myasthenia gravis (MG). Methods An extensive literature search was conducted by two independent investigators using PubMed/MEDLINE and Google Scholar from its inception to December 2020. Results Exacerbations of clinical symptoms
Syed Muhammad Ismail Shah, Farah Yasmin, Roha Saeed Memon, Nadia Nazir Jatoi, Ilma Saleh Savul, Sana Kazmi, Syed Abdullah Monawwer, Muhammad Daim Bin Zafar, Muhammad Sohaib Asghar, Muhammad Junaid Tahir, Ka Yiu Lee   +10 more
wiley   +1 more source

Comparison of RT-qPCR results of different gene targets for SARS-CoV-2 in asymptomatic individuals during COVID-19 pandemic

The EuroBiotech Journal, 2021
A reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is regarded as the most sensitive method available and is being used for screening procedure for all incoming passengers to Northern Cyprus for SARS-CoV-2.
Tuncel Gulten, Ergoren Mahmut Cerkez, Baddal Buket, Tulay Pinar, Arikan Ayse, Guler Emrah, Ozverel Cenk Serhan, Kaya Suer H., Sayan Murat, Sanlidag Tamer,   +10 more
doaj   +1 more source

Influence of SARS-CoV-2 variants’ spike glycoprotein and RNA-dependent RNA polymerase (nsp12) mutations on remdesivir docking residues

Медицинская иммунология, 2022
Rapid emergence and evolution of novel SARS-CoV-2 variants has raised concerns about their potential impact on efficiency of currently available vaccines.
Ali A. Dawood
doaj   +1 more source

Conformational Changes in Motif D of RdRPs as Fidelity Determinant [PDF]

Structure, 2012
RNA-dependent RNA polymerases (RdRPs) are the central players in both transcription and viral genome replication. Using NMR spectroscopy, Yang and colleagues (in this issue of Structure) show that the conformational changes in the structural motif D of poliovirus RdRP correlate with the nature of the bound nucleotide (correct versus incorrect), with a ...
Verdaguer, Núria, Ferrer-Orta, Cristina
openaire   +4 more sources

Analysis the Effectiveness of Remdesivir, Galidesivir, Sofosbuvir, Tenofovir and Ribavirin as Potential Therapeutic Drug target against SARS-Cov-2 RNA-Dependent RNA Polymerase (RdRp): An in Silico Docking Study [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  The active site of RdRp-CoV is highly conserved, with two successive and surface-accessible aspartates in a beta-turn structure. Antiviral drugs Remdesivir, Galidesivir, Tenofovir, Sofosbuvir, and Ribavirin are known as inhibitors of ...
Rajneesh Prajapat, Suman Jain
doaj  

Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets

Journal of Pure and Applied Microbiology, 2020
COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and MERS it’s structural and sequence similarity has abled ...
Hiran Kanti Santra, Debdulal Banerjee
doaj   +1 more source

Insights into the development of effective materials to suppress replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

AIMS Bioengineering, 2020
The life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiologic agent for coronavirus disease-19 (COVID-19), has been revealed, and the molecular mechanism of how this virus replicates has been studied.
Fumiaki Uchiumi, Yoko Ogino, Akira Sato, Sei-ichi Tanuma   +3 more
doaj   +1 more source