Results 21 to 30 of about 2,150 (202)

RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature

Microbiology Spectrum, 2022
The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen, Jiqin Wu, Xiaofeng Yang, Qiuli Sun, Su Liu, Farooq Rashid, Emmanuel Enoch Dzakah, Haiying Wang, Jufang Wang, Peng Gong, Shixing Tang   +10 more
doaj   +1 more source

Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type

Biomolecules, 2021
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) protein is the target for the antiviral drug Remdesivir (RDV). With RDV clinical trials on COVID-19 patients showing a reduced hospitalisation time.
Anwar Mohammad, Fahd Al-Mulla, Dong-Qing Wei, Jehad Abubaker   +3 more
doaj   +1 more source

TCM2COVID: A resource of anti‐COVID‐19 traditional Chinese medicine with effects and mechanisms

iMeta, Volume 1, Issue 4, December 2022., 2022
TCM2COVID documents over 280 traditional Chinese medicine formulas (including over 300 herbs) with detailed clinical evidence and therapeutic mechanism information; TCM2COVID records over 80 natural products with detailed potential therapeutic mechanisms; TCM2COVID launches a useful web server for querying, analyzing, and visualizing documented ...
Liping Ren, Yi Xu, Lin Ning, Xianrun Pan, Yuchen Li, Qi Zhao, Bo Pang, Jian Huang, Kejun Deng, Yang Zhang   +9 more
wiley   +1 more source

The importance of early diagnosis and views on newborn screening in metachromatic leukodystrophy: results of a Caregiver Survey in the UK and Republic of Ireland

Orphanet Journal of Rare Diseases, 2022
Metachromatic Leukodystrophy (MLD) is a rare, autosomal recessive lysosomal storage disorder caused by a deficiency of the enzyme arylsulfatase A (ARSA).
Georgina Morton, Sophie Thomas, Pat Roberts, Vivienne Clark, Jackie Imrie, Alexandra Morrison   +5 more
doaj   +1 more source

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain

Chemical Physics Letters, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain.
Julia Liang, Julia Liang, Eleni Pitsillou, Eleni Pitsillou, Tom C. Karagiannis, Tom C. Karagiannis, Helen Yu Meng Huang, Helen Yu Meng Huang, Andrew Hung   +8 more
openaire   +3 more sources

Over two decades of research on the marine RNA virosphere

iMeta, Volume 1, Issue 4, December 2022., 2022
Advances in meta‐omics provide a surge of marine RNA virus information. Deep marine virus discovery contributes greatly to the megataxonomy of RNA viruses. Understanding diversity and biogeography helps reveal the significance of marine RNA viruses, including evolutionary trajectories, hierarchical taxonomy, and ecological importance.
Meng‐en Liao, Yunyi Xie, Mang Shi, Jie Cui   +3 more
wiley   +1 more source

Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I

Viruses, 2023
Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou, Yue Huang, Lu Zhou, Mingma Li, Hui Jin   +4 more
doaj   +1 more source

Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach [PDF]

International Journal of Biological Macromolecules 163 (2020) 1787-1797, 2020
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been heavily invested in the discovery of a drug to combat SARS-CoV-2. It has been found that RNA-dependent RNA Polymerase (RdRp) plays a crucial role in SARS-CoV-2 replication, and thus could be a potential drug target.
arxiv   +1 more source

Cu(0)-RDRP of methacrylates in DMSO: importance of the initiator [PDF]

Polymer Chemistry, 2018
The controlled radical polymerization of methacrylates via Cu(0)-mediated RDRP is challenging in comparison to acrylates with most reports illustrating higher dispersities, lower monomer conversions and poorer end group fidelity relative to the acrylic analogues.
Glen R. Jones, Daniel J. Keddie, David M. Haddleton, Nuttapol Risangud, Alexandre Simula, Athina Anastasaki, Athina Anastasaki, Richard Whitfield   +7 more
openaire   +4 more sources

RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2 [PDF]

Journal of Biomolecular Structure and Dynamics, 2021
RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Mishra, Avinash, Rathore, Anurag S.
openaire   +4 more sources