Results 41 to 50 of about 2,150 (202)

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

Viruses, 2023
Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale, Robin J. Larson, Erin Jackson-Ward, Aditi Singh, Frances L. Koback, Lilly D. Engineer   +5 more
doaj   +1 more source

Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2)

Infection and Drug Resistance, 2021
Endriyas Kelta Wabalo, Abebe Dukessa Dubiwak, Mengistu Welde Senbetu, Tariku Sime Gizaw Department of Biomedical Sciences, Faculty of Medical Sciences, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Endriyas Kelta WabaloDepartment ...
Kelta Wabalo E, Dukessa Dubiwak A, Welde Senbetu M, Sime Gizaw T   +3 more
doaj  

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data [PDF]

Briefings in Bioinformatics, 2022
Abstract With advances in library construction protocols and next-generation sequencing technologies, viral metagenomic sequencing has become the major source for novel virus discovery. Conducting taxonomic classification for metagenomic data is an important means to characterize the viral composition in the underlying samples.
Tang, Xubo, Shang, Jiayu, Sun, Yanni
openaire   +2 more sources

Molecular screening of SARS‐CoV‐2 in dogs and cats from households with infected owners diagnosed with COVID‐19 during Delta and Omicron variant waves in Iran

Veterinary Medicine and Science, Volume 9, Issue 1, Page 82-90, January 2023., 2023
• SARS‐CoV‐2 was detected in 2 cats out of 20 examined (10%). • SARS‐CoV‐2 was not detected in dog samples. • The two cats positive for SARS‐CoV‐2 had clinical signs and were in close contact with COVID‐19 positive owners. Abstract Objective The emergence of SARS‐CoV‐2 infection in dogs and cats in different countries worldwide raises concerns that ...
Baharak Akhtardanesh, Maziar Jajarmi, Mohammadreza Shojaee, Sina Salajegheh Tazerji, Maziar Khalili Mahani, Pouneh Hajipour, Rasha Gharieb   +6 more
wiley   +1 more source

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

Tomato chlorosis virus, a promiscuous virus with multiple host plants and whitefly vectors

Annals of Applied Biology, Volume 182, Issue 1, Page 29-36, January 2023., 2023
Tomato chlorosis virus (ToCV) is an emerging plant virus first identified in the mid‐1990s affecting tomato in Florida. Today, the virus is present in at least 39 countries and territories around the world. ToCV prevalence in tomato has been reported to frequently reach 100%, with a consequent loss in production. Although ToCV infects mainly tomato, it
Elvira Fiallo‐Olivé, Jesús Navas‐Castillo   +1 more
wiley   +1 more source

Study of Eclipta prostrata compounds with potential inhibition of RNA-dependent RNA polymerase (RdRp) enzyme of Sars-CoV-2 virus using molecular docking

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023
The Covid-19 pandemic has emerged as a global health crisis, with no definitive end in sight. In this study, molecular docking was employed to screen compounds derived from Eclipta prostrata for their potential inhibitory effects on the RNA-dependent RNA
Hồ Thiên Hoàng, Nguyễn Thị Uyên Thanh, Quan Quốc Đăng, Bùi Đình Thạch   +3 more
doaj   +1 more source

Ribonucleoprotein transport in Negative Strand RNA viruses

Biology of the Cell, Volume 115, Issue 1, January 2023., 2023
The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot, Gina Cosentino, Marie‐Anne Rameix‐Welti   +2 more
wiley   +1 more source

Photo‐RAFT Polymerization Under Microwatt Irradiation via Unimolecular Photoinduced Electron Transfer

Angewandte Chemie, EarlyView.
Adding a base to PET‐RAFT polymerization significantly enhances the reactivity of acidic CTAs with Zn‐based photocatalysts, enabling polymerization under low light intensity (0.25 mW cm−2). This approach outperforms traditional PET‐RAFT, which showed no conversion under the same conditions.
Giovanni Lissandrini, Davide Zeppilli, Francesca Lorandi, Krzysztof Matyjaszewski, Abdirisak A. Isse, Laura Orian, Marco Fantin   +6 more
wiley   +2 more sources