A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy +2 more
core +1 more source
FEBS Open Bio, 2014 Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind +2 more
doaj +1 more source
Ultra-low volume oxygen tolerant photoinduced Cu-RDRP [PDF]
Polymer Chemistry, 2019 We introduce the first oxygen tolerant ultra-low volume (as low as 5 μL) photoinduced Cu-RDRP of a range of hydrophobic, hydrophilic and semi-fluorinated monomers.
Evelina Liarou +8 more
openaire +2 more sources
Recombinant viral RdRps can initiate RNA synthesis from circular templates [PDF]
RNA, 2005 The crystal structure of the recombinant hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) revealed extensive interactions between the fingers and the thumb subdomains, resulting in a closed conformation with an established template channel that should specifically accept single-stranded templates. We made circularized RNA templates and found
C T, Ranjith-Kumar, C C, Kao
openaire +2 more sources
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities [PDF]
, 2017 Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new ...
Coluccia, A. +9 more
core +1 more source
Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5. [PDF]
, 2020 During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles.
Goodbourn, S +6 more
core +3 more sources
Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching [PDF]
Journal of Virology, 2019 Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1).
Subbiah, Jeeva +7 more
openaire +2 more sources
Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination [PDF]
, 2008 Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Bragard, C. +7 more
core +3 more sources
The problem of SARS-CoV-2 virus resistance to direct-acting antivirals
Биопрепараты: Профилактика, диагностика, лечениеINTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich +6 more
doaj +1 more source
Molecular and phylogenetic characterization of honey bee viruses, Nosema microsporidia, protozoan parasites, and parasitic mites in China [PDF]
, 2008 China has the largest number of managed honey bee colonies, which produce the highest quantity of honey and royal jelly in the world; however, the presence of honey bee pathogens and parasites has never been rigorously identified in Chinese apiaries.
Yang, Bu +3 more
core +5 more sources