Results 41 to 50 of about 53,016 (292)
Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP
Nucleic Acids Research, 2021 Replication of the ∼30 kb-long coronavirus genome is mediated by a complex of non-structural proteins (NSP), in which NSP7 and NSP8 play a critical role in regulating the RNA-dependent RNA polymerase (RdRP) activity of NSP12.
Mahamaya Biswal +8 more
semanticscholar +1 more source
Inter- and Intramolecular recombinations in the Cucumber Mosaic Virus genome related to adaptation to Alstroemeria [PDF]
, 2002 In four distinct alstroemeria-infecting cucumber mosaic virus (CMV) isolates, additional sequences of various lengths were present in the 3' nontranslated regions of their RNAs 2 and 3, apparently the result of intra- and intermolecular recombination ...
Chen, Y.K., Goldbach, R.W., Prins, M.W.
core +7 more sources
Orphanet Journal of Rare Diseases, 2022 Metachromatic Leukodystrophy (MLD) is a rare, autosomal recessive lysosomal storage disorder caused by a deficiency of the enzyme arylsulfatase A (ARSA).
Georgina Morton +5 more
doaj +1 more source
Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
doaj +1 more source
Scientific Reports, 2021 Corona Virus Disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has brought the world to a standstill and threatened human lives. Many methods are known to date to detect this virus.
H. Tombuloglu +5 more
semanticscholar +1 more source
Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
ACS Omega, 2023 Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegylated interferon-α and ribavirin are the only antiviral agents available for the treatment of chronic patients.
Preeti Hooda +4 more
openaire +3 more sources
AIMS Bioengineering, 2020 The life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiologic agent for coronavirus disease-19 (COVID-19), has been revealed, and the molecular mechanism of how this virus replicates has been studied.
Fumiaki Uchiumi +3 more
doaj +1 more source
PLoS ONE, 2021 A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its epicenter in China to more than 150 countries across six continents.
Woong Sik Jang +10 more
doaj +1 more source
ICTV Virus Taxonomy Profile: Chrysoviridae [PDF]
, 2019 Members of the family Chrysoviridae are isometric, non-enveloped viruses with segmented, linear, dsRNA genomes. There are 3–7 genomic segments, each of which is individually encapsidated.
Castón, José R. +8 more
core +2 more sources
Bioinformation, 2021 Treatment of SARS-CoV-2 targeting its RNA dependent RNA polymerase (RdRp) is of current interest. Remdesivir has been approved for the treatment of COVID-19 around the world. However, the drug has been linked with pharmacological limitations like adverse
Shashank M. Patil +6 more
semanticscholar +1 more source