Results 81 to 90 of about 2,150 (202)

Detection and Characterization of Cucumis melo Cryptic Virus, Cucumis melo Amalgavirus 1, and Melon Necrotic Spot Virus in Cucumis melo

Viruses, 2019
Three RNA viruses—Cucumis melo cryptic virus (CmCV), Cucumis melo amalgavirus 1 (CmAV1), and melon necrotic spot virus (MNSV)—were identified from a melon (Cucumis melo) transcriptome dataset.
Binhui Zhan, Mengji Cao, Kaina Wang, Xifeng Wang, Xueping Zhou   +4 more
doaj   +1 more source

Three‐Dimensional Visualization of Remdesivir and the SARS‐CoV‐2 RdRp

The FASEB Journal, 2021
The SARS-CoV-2 virus, which causes the COVID-19 disease, has been a focus of concern around the world, setting records as a modern-day pandemic. The Center for Disease Control has confirmed over 86 million cases in the world with over 1.9 million confirmed deaths as of January 5, 2021. SARS-CoV-2 continues to be a serious threat to global public health,
Binh Nguyen, Sierra Dale, Laura Rusch-Salazar, Karshana Kalyanaraman, Asal Eid   +4 more
openaire   +1 more source

Continuous Flow Block Copolymer Nanoaggregate Synthesis and Their Flow Dialysis Purification

Chemistry–Methods, EarlyView.
This work details the methodology for the synthesis of block copolymer nanoparticles through continuous flow self‐assembly and purification via flow dialysis. Nanoaggregates are formed by mixing block copolymer solutions in THF with water, followed by dialysis to eliminate excess solvent.
Gayathri Dev Ammini, Lakshani J. Weerarathna, Tanja Junkers   +2 more
wiley   +1 more source

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

Nature Communications, 2020
During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological ...
Meihua Wang, Rui Li, Bo Shu, Xuping Jing, Han-Qing Ye, Peng Gong   +5 more
doaj   +1 more source

Protein-ligand interaction study to identify potential dietary compounds binding at the active site of therapeutic target proteins of SARS-CoV-2 [PDF]

arXiv, 2020
Objective: Total 186 biologically important phenylpropanoids and polyketides compounds from different Indian medicinal plants and dietary sources were screened to filter potential compounds that bind at the active site of the therapeutic target proteins of SARS-CoV-2.
arxiv  

Interaction between Hantavirus Nucleocapsid Protein (N) and RNA-Dependent RNA Polymerase (RdRp) Mutants Reveals the Requirement of an N-RdRp Interaction for Viral RNA Synthesis [PDF]

Journal of Virology, 2014
ABSTRACT Viral ribonucleocapsids harboring the viral genomic RNA are used as the template for viral mRNA synthesis and replication of the viral genome by viral RNA-dependent RNA polymerase (RdRp). Here we show that hantavirus nucleocapsid protein (N protein) interacts with RdRp in virus-infected cells. We mapped the RdRp binding domain at the
Zekun Wang, Mohammad A. Mir, Erdong Cheng   +2 more
openaire   +3 more sources

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, EarlyView.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication

Frontiers in Microbiology, 2018
Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or de novo RNA synthesis by RNA-dependent RNA polymerase (RdRp).
Ji-Hye Lee, Beom Seok Park, Intekhab Alam, Kang R. Han, Scott B. Biering, Soo J. Kim, Jayoung Choi, Jong H. Seok, Mi S. Chung, Ho M. Kim, Seungmin Hwang, Seungmin Hwang, Kyung H. Kim   +12 more
doaj   +1 more source

Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.

PLoS ONE, 2021
To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed.
Clément Madru, Ayten Dizkirici Tekpinar, Sandrine Rosario, Dariusz Czernecki, Sébastien Brûlé, Ludovic Sauguet, Marc Delarue   +6 more
doaj   +1 more source