Results 251 to 260 of about 915,551 (289)
Some of the next articles are maybe not open access.
Reactive Astrocytes in Glioblastoma Multiforme
Molecular Neurobiology, 2018Despite the multidisciplinary integration in the therapeutic management of glioblastoma multiforme (GBM), the prognosis of GBM patients is poor. There is growing recognition that the cells in the tumor microenvironment play a vital role in regulating the progression of glioma.
Xiudong Guan +4 more
openaire +2 more sources
Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits
Physiological Reviews, 2014Astrocytes are the most abundant cells in the central nervous system (CNS) that provide nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis maintaining functions. During the past two decades, astrocytes emerged also as increasingly important regulators of neuronal functions including the generation of new nerve ...
M. Pekny, M. Pekna
openaire +2 more sources
Ultrastructural study of enzymes in reactive astrocytes: Clarification of astrocytic activity
The Histochemical Journal, 1982Enzymes in reactive of the cerebral cortex were examined at the ultrastructural level in an attempt to resolve some conflicting aspects of astrocytic activity. Correlations between morphological and enzyme changes after injury established that the apparent increase in oxidative enzyme activity was exclusively mitochondrial and not an artefactual ...
S Y, Al-Ali, N, Robinson
openaire +2 more sources
Dysregulation of polarity proteins in astrocyte reactivity
Ageing Research Reviews, 2023Astrocytes are highly polarized neuroglial cells. Polarity is the basis for many of the diverse roles that astrocytes play in the normal and injured brain. Astrocytes are generally dormant and non-migratory under normal physiological conditions, where they perform a wide variety of intricate and essential tasks in preserving CNS homeostasis.
openaire +2 more sources
Heterogeneity of Reactive Astrocytes
1993Astrocytic changes are one of the hallmarks of the response of the adult mammalian central nervous system (CNS) to injury. These changes that include increased expression of glial fibrillary acidic protein (GFAP), proliferation and hypertrophy, have been described as giving rise to a glial “scar”, which is widely suggested as being detrimental to axon ...
Samuel David, Rhonda Ness
openaire +1 more source
Diversity in Reactive Astrocytes
2002Normal astrocytes in the adult undergo hypertrophy and proliferation and transform into reactive astrocytes following many types of central nervous system (CNS) injury (1–5). This process is termed astrogliosis and may result in the formation of a glial scar.
Sudarshan K. Malhotra +1 more
openaire +1 more source
Developmental Brain Research, 1983
Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxidase staining and by morphometric ...
L C, Doering, S, Fedoroff, R M, Devon
openaire +2 more sources
Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxidase staining and by morphometric ...
L C, Doering, S, Fedoroff, R M, Devon
openaire +2 more sources
Reactive astrocytes--a review.
Cytobios, 1990This review provides an historical and current perspective on astrocytes in the CNS, detailing their morphological and biochemical diversity, origins and transformation to reactive astrocytes in experimental lesions and clinical disease states which result in gliosis.
S K, Malhotra, T K, Shnitka, J, Elbrink
openaire +1 more source
Reactive Astrocytes in Neural Repair and Protection
The Neuroscientist, 2005Reactive astrocytosis occurs prominently in response to all forms of CNS injury or disease. The functions of reactive astrocytes are not well understood, and both harmful and beneficial activities have been attributed to these cells. The basic process of reactive astrocytosis is conserved in vertebrate evolution, suggesting fitness-enhancing benefits ...
openaire +2 more sources