Results 151 to 160 of about 21,361,330 (197)

Modeled structure-based computational redesign of a glycosyltransferase for the synthesis of rebaudioside D from rebaudioside A

Biochemical Engineering Journal, 2020
Abstract Engineering of enzymes without crystal structures and homologous structures is a great challenge for structure-based computational enzyme design. In this study, a computational strategy that combines protein structure prediction, sequence optimization, and molecular dynamics simulation was developed to improve the catalytic efficiency of the
Min Lin, Fei Wang, Yushan Zhu
openaire   +1 more source

Highly efficient synthesis of mono-β-1,6-Glucosylated Rebaudioside A derivative catalyzed by glycosyltransferase YjiC.

Carbohydrate Research, 2022
Steviol glycosides have attracted great interest because of their high levels of sweetness and safety, and absence of calories. Improvement of their sensory qualities via glycosylation modification by glycosyltransferase is a research hotspot.
Lifeng Yang, Qian Ping, Zhenbo Yuan, Jiejuan Jiang, Baodang Guo, Changmei Liu, Y. Rao, Jinsong Shi, Yan Zhang   +8 more
semanticscholar   +1 more source

In vitro metabolism of rebaudioside B, D, and M under anaerobic conditions: Comparison with rebaudioside A

Regulatory Toxicology and Pharmacology, 2014
The hydrolysis of the steviol glycosides rebaudioside A, B, D, and M, as well as of steviolbioside (a metabolic intermediate) to steviol was evaluated in vitro using human fecal homogenates from healthy donors under anaerobic conditions. Incubation of each of the rebaudiosides resulted in rapid hydrolysis to steviol. Metabolism was complete within 24h,
Sidd, Purkayastha, George, Pugh, Barry, Lynch, Ashley, Roberts, David, Kwok, Stanley M, Tarka   +5 more
openaire   +2 more sources

The non-nutritive sweetener rebaudioside a enhances phage infectivity

Scientific Reports
Non-nutritive sweeteners (NNS) are widely employed in foodstuffs. However, it has become increasingly evident that their consumption is associated with bacterial dysbiosis, which, in turn, is linked to several health conditions, including a higher risk ...
L. Marongiu, Ewa Brzozowska, Jan Brykała, Markus Burkard, H. Schmidt, Bożena Szermer-Olearnik, S. Venturelli   +6 more
semanticscholar   +1 more source

Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.

Toxicology and Applied Pharmacology, 2021
Hesperetin (HSP) has excellent biological activities with poor water solubility which limits its clinical development. In this study, we successfully prepared a novel, self-assembled micelle based on Rebaudioside A (RA) for oral delivery of HSP with ...
Jun Wang, Qiqi Li, Zekun Chen, Xianghui Qi, Xianggen Wu, Guohu Di, Junting Fan, Chuan-Yong Guo   +7 more
semanticscholar   +1 more source

Synthesis and characterization of sodium alginate/poly(N-vinylpyrrolidone) nano-carrier loaded with rebaudioside A and/or stevioside for anticancer drug delivery.

International Journal of Biological Macromolecules
Stevioside and rebaudioside A revealed anticancer effects against diversity of cancers, such as colon, breast and liver cancers. Rebaudioside A can trigger apoptosis in cancer cells via activation of caspase-dependent pathway.
Shaymaa M. Mohamed, Ahmad K B Aljohani, Ahmed El-morsy, Rwaida A Al Haidari, Mshref A.A. Alamri, Yahya A. Maqnas, Aishah M. Alsibaee, M. A. Mostafa, D. E. Keshek, M. Mohamed, Soad A. L. Bayoumi, Samir A. Salama, Khaled El‐Adl   +12 more
semanticscholar   +1 more source

Evaluation of Stevioside and Rebaudioside A in Sri Lankan Food and Beverages, Using A Validated Hplc Method

International Journal of Latest Technology in Engineering Management & Applied Science
: Currently, there is a trend of using non-caloric high-intense sweeteners, as substitutes for sugars in food, carbonated and non-carbonated beverages to acquire the required sweet taste.
P.S.F Perera, K.R.R Mahanama, H.P.P.S Somasiri   +2 more
semanticscholar   +1 more source

RQ3, A Natural Rebaudioside D Isomer, Was Obtained from Glucosylation of Rebaudioside A Catalyzed by the CGTase Toruzyme 3.0 L

Journal of Agricultural and Food Chemistry, 2019
In this study, a monoglucosyl rebaudioside A product was isolated from the mixture of glucosylated rebaudioside A obtained from the most reported and industrial used cyclodextrin glycosyl transferase, Toruzyme 3.0 L (CGTase, Toruzyme 3.0 L). The molecular structure of the monoglucosyl rebaudioside A was characterized using LC-MS/MS and methylation ...
Qingbin Guo, Tongtong Zhang, Nifei Wang   +2 more
exaly   +3 more sources

Rebaudioside F, a diterpene glycoside from Stevia rebaudiana

Phytochemistry, 2002
The sweet diterpenoid glycoside, rebaudioside F, was isolated from leaves of a high rebaudioside C producing line of Stevia rebaudiana, and its structure was established by chemical and spectral studies.
Christopher W Kirby
exaly   +3 more sources

A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin

International journal of pharmaceutics: X
Cisplatin-induced acute kidney injury (AKI) is a significant clinical challenge, primarily characterized by inflammatory responses and oxidative stress. This study aimed to develop a myricetin (Myr) loaded Rebaudioside A (RA) nanomicelle delivery system (
Tian Wang, Z. Gao, Chuanlong Guo, Wenyong Zhu   +3 more
semanticscholar   +1 more source