Results 111 to 120 of about 6,562 (195)

Specificity and reversibility of chemotactic deactivation of human monocytes [PDF]

, 1981
The chemotactic deactivation of human monocytes was studied to provide insight into the mechanism of chemotaxis. Deactivation was dependent on the dose of chemoattractant and time of incubation.
Falk, Werner, Leonard, E.J.
core   +1 more source

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality [PDF]

, 2013
A significant challenge in chemistry is to rationally reproduce the functional potency of a protein in a small molecule, which is cheaper to manufacture, non-immunogenic, and also both stable and bioavailable.
A Ghassemian, A Jacob, A Sonesson, AS Kirshenbaum, BL Wu, BN Bullock, CC Scully, D Seebach, DP Fairlie, EB Grant, F Denonne, F Denonne, G Bajic, G Ruiz-Gomez, H Takematsu, H Yin, H-C Wilken, J Kildsgaard, J Lim, J Venkatraman, JA Ember, JDA Tyndall, JM Scholtz, JZ Sun, KD Stigers, L Dreier, LM Proctor, M Pasupuleti, MN Munkonda, N Mizutani, NP Gerard, P Hutamekalin, P-J Haas, PF Zipfel, R Huber, RS Ames, SL Masters, TE Hugli, TE Hugli, TH Chao, VA Bokisch, WF DeGrado, Y Fukuoka, Y Mamane, Z Tang   +44 more
core   +1 more source

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Aquaculture Nutrition
Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear.
Yixin Gu, Yu Zhan, Yafeng Guo, Wenyuan Hua, Xin Qi, Zhizhi Gu, Shengnan Cao, Yan Chen, Zhuang Xue, Wei Wang   +9 more
doaj   +1 more source

The pathophysiology of the complement system in leprosy [PDF]

, 1991
The complement system, which consists of a group of proteins and glycoproteins, generally serves to amplify the effects of the interaction of antigen with antibody.
Ramanathan, V D
core  

Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis

ESC Heart Failure
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF).
Tess E. Peterson, Joao A.C. Lima, Sanjiv J. Shah, David A. Bluemke, Alain G. Bertoni, Yongmei Liu, Debby Ngo, Vinithra Varadarajan, Josyf C. Mychaleckyj, Craig W. Johnson, Bruce M. Psaty, Clary B. Clish, Kent D. Taylor, Peter Durda, Russell P. Tracy, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, James S. Pankow   +19 more
doaj   +1 more source

Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core  

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis [PDF]

, 2017
Adrian W. S. Ho, Alessandra Mortellaro, Baalasubramanian Sivasankar, Federica Laudisi, Gim Gee Teng, Hanif J. Khameneh, Heidi Derks, Matheswaran Kandasamy   +7 more
core   +1 more source

Targeting C3a and C5a Signaling-A Game Changer for Cancer Therapy? [PDF]

Biology (Basel)
Hudgins H, Molina V, Wiernicki S, Okwuegbe K, Feng X, Wang H.   +5 more
europepmc   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver

, 2018
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H. L., Gotze, O.   +5 more
openaire   +1 more source

Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease. [PDF]

Immune Netw
Shadid A, Hok KD, Domozhirov AY, Weng-Mills T, Doursout MF, Banda NK, Restrepo MI, Shivshankar P.   +7 more
europepmc   +1 more source