Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]
, 2008 Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S. +5 more
core +2 more sources
Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat [PDF]
Hypertension, 2006 Whereas angiotensin (Ang) II is the major effector peptide of the renin–angiotensin system, its metabolite, des-aspartyl1-Ang II (Ang III), may also have biologic activity. We investigated the effects of renal interstitial (RI) administration of candesartan (CAND), a specific Ang II type 1 receptor (AT1) blocker, with and without coinfusion of PD ...
Shetal H, Padia +3 more
openaire +2 more sources
Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy
The Scientific World Journal, 2008 Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
doaj +1 more source
Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]
, 2004 <p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C. +5 more
core +1 more source
Roles and functions of Atp6ap2 in the brain
Neural Regeneration Research, 2018 The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke +1 more
doaj +1 more source
Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]
PLoS ONE, 2016 Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda +12 more
doaj +1 more source
Angiotensin II Type 2 Receptor–Bradykinin B 2 Receptor Functional Heterodimerization [PDF]
Hypertension, 2006 Angiotensin II type 2 (AT 2 R) or bradykinin B 2 (B 2 R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT 2 R and B 2 R are simultaneously activated in vivo ...
Peter M, Abadir +3 more
openaire +2 more sources
Hypertension: Renin-Angiotensin-Aldosterone System Alterations [PDF]
, 2015 Blockers of the renin-angiotensin-aldosterone system (RAAS), that is, renin inhibitors, angiotensin (Ang)-converting enzyme (ACE) inhibitors, Ang II type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the ...
Danser, A.H.J. (Jan) +4 more
core +1 more source
Neuroprotective effect of angiotensin II type 2 receptor during cerebral ischemia/reperfusion
Neural Regeneration Research, 2016 Angiotensin II type 2 receptor (AT2R) activation has been shown to protect against stroke, but its precise mechanism remains poorly understood. We investigated whether the protective effect of AT2R against ischemia/reperfusion injury is mediated by the ...
Chun-ye Ma, Lin Yin
doaj +1 more source
Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF [PDF]
, 2017 The natriuretic peptide (NP) system, which includes atrial natriuretic peptide, B-type natriuretic peptide, and C-type natriuretic peptide, has an important role in cardiovascular homeostasis, promoting a number of physiological effects including ...
Rubattu, Speranza Donatella +1 more
core +2 more sources