Results 11 to 20 of about 5,853 (186)

Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life

Journal of Translational Medicine, 2009
Background The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor ...
Glen Daniel, Cox Robert W, Butman John A, Fung Steve H, Kanevsky Ariel S, Sarin Hemant, Reynolds Richard, Auh Sungyoung   +7 more
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Polymorphisms in the Bradykinin B2 Receptor Gene and Childhood Asthma [PDF]

Biological Chemistry, 2001
Bradykinin has been suggested as one of the key mediators of bronchial asthma. Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene. Study of these polymorphisms in 77 children with asthma and 73 controls revealed no association. However, when comparing the asthmatics according to their age at onset
Kusser, B., Braun, A., Praun, M., Illi, S., Mutius, Erika von, Roscher, A. A.   +5 more
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The Pathophysiology of Hereditary Angioedema

World Allergy Organization Journal, 2010
Hereditary angioedema (HAE) causes recurrent episodes of angioedema that may be very severe and are frequently associated with significant morbidity and even mortality. Understanding the pathophysiology of this disease is crucial for proper diagnosis and
Bruce L Zuraw, MD
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Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist Peptide from Ranid Frogs

The Scientific World Journal, 2014
The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions
Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw   +8 more
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Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
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Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Nature Communications, 2023
An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo   +14 more
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Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle

Frontiers in Medicine, 2022
Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in the pathophysiology of detrusor overactivity. The present study aims to elucidate the signaling pathways of BK-induced detrusor muscle contraction, with the goal of
Kinga Borsodi, Helga Balla, Péter József Molnár, Péter József Molnár, Ádám Lénárt, István Kenessey, András Horváth, Attila Keszthelyi, Miklós Romics, Attila Majoros, Péter Nyirády, Stefan Offermanns, Zoltán Benyó   +12 more
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Regulation of bradykinin B₂‐receptor expression by oestrogen [PDF]

British Journal of Pharmacology, 1997
Tissue kallikrein is overexpressed in the kidney of female rats, this sexual dimorphism being associated with a greater effect of early blockade of bradykinin B2‐receptors on female blood pressure phenotype. We evaluated the effect of ovariectomy and oestradiol benzoate (50 μg kg−1 every two days for two weeks) on the vasodepressor response to intra ...
Madeddu P, Emanueli C, Song Q, VARONI, Maria Vittoria, DEMONTIS, Maria Piera, Anania V, GLORIOSO, Nicola Filippo, Chao J. Br J. P.h.a.r.m.a.c.o.l. 1997 Aug, 121:1763 9. Erratum in: Br J. Pharmacol 1998 Apr, 123:742   +9 more
openaire   +5 more sources

Thromboxane A2 mediates cation-induced airway hyperresponsiveness through the bradykinin B2 receptor in guinea pigs

Allergology International, 1999
To elucidate the mechanisms of cationic protein-induced airway hyperresponsiveness (AHR), the airway response to methacholine, and the concentrations of thromboxane B2 (TXB2) and 6-keto-PGF1α in the bronchoalveolar lavage fluid (BALF) of guinea-pigs were
Tomohiko Shirotani, Hitoshi Maeda, Yoshihiro Nishimura, Mitsuhiro Yokoyama   +3 more
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Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium

Mediators of Inflammation, 1993
The effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events.
Yusuf Öztürk, V. Melih Altan, Nuray Yıdızoğlu-Arı, Orhan Altınkurt   +3 more
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