Results 21 to 30 of about 5,853 (186)
Neuroprotection of bradykinin/bradykinin B2 receptor system in cerebral ischemia
Biomedicine & Pharmacotherapy, 2017 Bradykinin B2 receptor (B2R) activated by its endogenous ligand bradykinin participates in various physiological processes including neurogenesis, neuronal differentiation, and control of inflammation and blood pressure. Besides these effects, B2R has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury.
Bingyuan, Ji +5 more
openaire +2 more sources
Frontiers in Medicine, 2019 Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of atherosclerosis, we investigated the impact of the B2 bradykinin receptor, Bdkrb2, on atherosclerotic ...
Alexander Perhal +6 more
doaj +1 more source
Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice
Frontiers in Aging Neuroscience, 2019 Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS)
Mariana Toricelli +8 more
doaj +1 more source
Calreticulin enhances B2 bradykinin receptor maturation and heterodimerization [PDF]
Biochemical and Biophysical Research Communications, 2009 In different native tissues and cells the receptor for the vasodepressor bradykinin, B(2), forms dimers with the receptor for the vasopressor angiotensin II, AT(1). Because AT(1)/B(2) heterodimers may contribute to enhanced angiotensin II-stimulated signaling under pathophysiological conditions, we analyzed mechanisms of AT(1)/B(2) heterodimerization ...
Abd Alla, J +4 more
openaire +3 more sources
P4.11 LOWER LIMB VASOMOTOR AND FIBRINOLYTIC EFFECTS OF KININ RECEPTOR AGONISTS IN MAN
Artery Research, 2009 Background: Vascular B1 kinin receptor expression is upregulated in human atheroma and the presence of angiotensin-converting enzyme inhibition (ACEi), but its role in man remains unclear.
N.L. Cruden +5 more
doaj +1 more source
Neprilysin Inhibitors Potentiate Effects of Bradykinin on B2 Receptor [PDF]
Hypertension, 2002 Some beneficial effects of angiotensin-I–converting enzyme (ACE, kininase II) inhibitor therapy are attributed to enhancing the activity of bradykinin on its B 2 receptor. Independent of inhibition of bradykinin hydrolysis, ACE inhibitors enhance the action of bradykinin on its B 2 receptor ...
Peter A, Deddish +5 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2007 ATP has broad functions as an autocrine/paracrine molecule. The mode of ATP release and its intracellular source, however, are little understood. Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the ...
Yumei Zhao +5 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Background: The blood–brain barrier (BBB) describes the brain’s highly specialized capillaries, which form a dynamic interface that maintains central nervous system (CNS) homeostasis.
Sergio R. Rodríguez-Massó +6 more
doaj +1 more source
Bradykinin and its role in osteoarthritis
Reumatismo, 2013 Osteoarthritis (OA), the most common joint disorder, is a disease involving all the articular structures. It presents both degenerative and inflammatory aspects. Recently, the important role of Bradykinin (BK), a phlogistic mediator, has been proposed in
L. De Falco +3 more
doaj +1 more source
Allergy, Asthma & Clinical Immunology, 2021 Background The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks.
Mar Guilarte +14 more
doaj +1 more source