Results 41 to 50 of about 5,853 (186)

TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies

Cellular Physiology and Biochemistry, 2016
Background/Aims: The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the susceptibility and severity of osteoarthritis (OA); however, the underlying mechanisms are unclear. In this study, we investigated the
Shuo Chen, Lei Zhang, Ruonan Xu, Yunfan Ti, Yunlong Zhao, Liwu Zhou, Jianning Zhao   +6 more
doaj   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1034-e1044, August 2026.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

The temporal relationship between the neural and vascular actions of kallidin within the nose

Mediators of Inflammation, 1993
The time course of effect of the B2-receptor agonist kallidin (K) on induced changes of nasal airflow, rhinorrhoea, nasal pain, sneezing and nasal microvascular leakage has been examined and compared with its B2 metabolite agonist bradykinin (B) and the ...
K. Rajakulasingam, L. C. K. Lau, R. Polosa, M. K. Church, S. T. Holgate, P. H. Howarth   +5 more
doaj   +1 more source

Interindividual variability in static apnoea performance is partly explained by genetic factors

Experimental Physiology, Volume 111, Issue 8, Page 3718-3730, 1 August 2026.
Abstract A large interindividual variability exists in maximal apnoea duration and the physiological adjustments that occur during apnoea. Although a few genes have been found to be associated with some of the cardiovascular responses during apnoea, the extent to which genetic and environmental factors contribute to individual differences in apnoea ...
Anastasios Makris, Alexandros Sotiridis, Nickos Geladas, Kalliopi Gkouskou, Vassilis Klissouras, Maria D. Koskolou   +5 more
wiley   +1 more source

Advanced Modelling and Functional Characterization of B2 Bradykinin Receptor [PDF]

International Journal Bioautomation, 2015
Hereditary angioedema (giant hives) is an autosomal dominant malady characterized by repetitive episodes of probably life-threatening angioedema due to a partial deficiency of C1 inhibitor.
Muhammad Saad Khan, Sahar Fazal
doaj  

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Journal of Translational Medicine, 2019
Background Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.
Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack, Jean-Pierre Girolami   +7 more
doaj   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Stimuli‐Responsive Aggregation‐Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications

Small Science, Volume 6, Issue 7, July 2026.
pH, enzyme, hypoxia/redox, temperature, and external trigger‐responsive AIE materials for tumor imaging and therapy. Smart‐responsive aggregation‐induced emission (AIE) materials have emerged as promising bio‐nanomaterials for tumor diagnosis and therapy due to their enhanced fluorescence in aggregated states, overcoming the aggregation‐caused ...
Zhaohua Xu, Deyue Kong, Xiaoru Li, Miao Zhu, Haili Yan, Chenyang Zhang, Xiaochun Wang, Duiping Feng, Jiangfeng Du   +8 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source