Results 61 to 70 of about 5,853 (186)

D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases

Frontiers in Pharmacology, 2018
We previously reported hypotensive and vasodilator effects from C-terminally extended bradykinin (BK) sequences that behave as B2 receptor (B2R) agonists activated by vascular or plasma peptidases.
Hélène Bachelard, Xavier Charest-Morin, François Marceau   +2 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons

Frontiers in Cellular Neuroscience, 2015
Bradykinin (BK) and its receptors (B1 and B2 receptors) play important roles in inflammatory nociception. However, the patterns of expression and physiological/pathological functions of B1 and B2 receptors in trigeminal ganglion (TG) neurons remain to be
Aya eKawaguchi, Masaki eSato, Maki eKimura, Takaki eYamazaki, Hitoshi eYamamoto, Masakazu eTazaki, Tatsuya eIchinohe, Yoshiyuki eShibukawa   +7 more
doaj   +1 more source

Effect of icatibant on sweating-induced dermal pain

Journal of Cutaneous Immunology and Allergy
BackgroundExposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli ...
Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide   +11 more
doaj   +1 more source

Genetic associations of bradykinin type 2 receptor, alpha-adrenoceptors and endothelial nitric oxide synthase with blood pressure and left ventricular mass in outpatients without overt heart disease

International Journal of Cardiology: Heart & Vasculature, 2018
Background: Physiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function.
Rafael Amorim Belo Nunes, Larissa Barbosa Lima, Nelson Ithiro Tanaka, Alexandre da Costa Pereira, José Eduardo Krieger, Alfredo José Mansur   +5 more
doaj   +1 more source

Effect of 3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine-2-ones on the bradykinin-induced smooth muscle contraction

Regulatory Mechanisms in Biosystems, 2017
Damage to tissue, inflammation and disruption of normal functioning of organs are often accompanied by pain. In pain perceptions, the kinin-kallikrein system with bradykinin as mediator is very important.
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, O. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

International Journal of Hypertension, 2017
Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension.
Takuto Nakamura, Masanobu Yamazato, Akio Ishida, Yusuke Ohya   +3 more
doaj   +1 more source

A novel anti-thrombotic mechanism mediated by the receptors of the kallikrein/kinin and renin-angiotensin systems

Frontiers in Medicine, 2016
The contact activation (CAS) and kallikrein/kinin (KKS) systems regulate thrombosis risk two ways. First, the CAS influences contact activation-induced factor XI activation and thrombin formation through the hemostatic cascade.
Alvin H. Schmaier
doaj   +1 more source

Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering

Journal of Spectroscopy, 2014
Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0 ...
Dominika Skołuba, Dariusz Sobolewski, Adam Prahl, Edyta Proniewicz   +3 more
doaj   +1 more source

Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors

Frontiers in Medicine, 2019
Background:Plasmodium falciparum, the etiologic agent of malaria, is a major cause of infant death in Africa. Although research on the contact system has been revitalized by recent discoveries in the field of thrombosis, limited efforts were done to ...
Leandro S. Silva, Alessandro S. Pinheiro, Douglas E. Teixeira, Rodrigo P. Silva-Aguiar, Diogo B. Peruchetti, Julio Scharfstein, Celso Caruso-Neves, Celso Caruso-Neves, Ana Acacia S. Pinheiro   +8 more
doaj   +1 more source