Results 51 to 60 of about 5,853 (186)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Notes on the Physiopathology of the Kinin-Mediated Angioedema Associated with Angiotensin-Converting Enzyme Inhibition

Drugs and Drug Candidates
Angiotensin-converting enzyme (ACE) inhibitors (ACEis) are one of the most successful drug classes for the treatment of hypertension and the prevention of its cardiovascular complications.
François Marceau
doaj   +1 more source

Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids. [PDF]

PLoS ONE, 2013
The molecular and cellular mechanisms by which long-chain polyunsaturated fatty acids (LCPUFA) exert their beneficial effects on cardiovascular health remain obscure.
Jose Candelario, Mirianas Chachisvilis
doaj   +1 more source

Genome Mining Approaches for Toxicant Discovery: A Case Study Examining Receptor Proteins for Pest Management in New Zealand

New Zealand Journal of Zoology, Volume 53, Issue 2, June 2026.
Pest control is a global challenge for agriculture and biodiversity conservation, with the use of existing vertebrate pesticides increasingly constrained by regulatory, environmental, and social pressures. There is an urgent need for safer and more species‐selective toxicants, but the development of novel vertebrate pesticides remains technically ...
Erica R. Hendrikse, Natalie J. Forsdick, Wanting Jiao, Brian Hopkins   +3 more
wiley   +1 more source

Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa

Mediators of Inflammation, 2009
Bradykinin (BK) has been tobe thought a potent mediator involved in allergic rhinitis because BK was recovered from the nasal lavage fluid of allergic rhinitis patients after allergen provocation and BK receptor antagonists relief nasal allergic symptoms.
Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Himi   +2 more
doaj   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Enhancement of blood-tumor barrier permeability by Sar-[D-Phe8]des-Arg9BK, a metabolically resistant bradykinin B1 agonist, in a rat C6 glioma model

BMC Neuroscience, 2004
Background While it is well known that bradykinin B2 agonists increase plasma protein extravasation (PPE) in brain tumors, the bradykinin B1 agonists tested thus far are unable to produce this effect.
Walz Roger, Carlotti Carlos, Bianchin Marino, Lobão-Soares Bruno, Cardoso Ronie, Alvarez-Silva Márcio, Trentin Andréa, Nicolau Mauro   +7 more
doaj   +1 more source

Loss of Striatal Bradykinin B2 Receptor Alters Anxiety and Motivational Behaviors in Male Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Impaired signaling of the bradykinin B2 receptor (B2R) in dorsal striatal neurons decreases anxiety‐like behavior and sucrose preference while enhancing voluntary running in mice. These results reveal a novel role for B2R in dopaminergic circuits that modulate motivation and emotional behavior.
Mariana Rosolen Tavares, Ronaldo Carvalho Araujo, Marina Galleazzo Martins, Jose Donato Jr, Michael Bader, Frederick Wasinski   +5 more
wiley   +1 more source

Registry‐Based Analysis of Treatment and Retreatment Attacks of Hereditary Angioedema

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 986-988, August 2026.
Roman Hakl, Jan Baroš, Marta Sobotková, Radana Zachová, Pavlína Králíčková, Martina Vachová, Irena Krčmová, Michal Svoboda, Vendula Szmucová, Monika Skotáková, Jiří Litzman   +10 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source