Results 101 to 110 of about 53,933 (241)

Non-genomic effects of nuclear receptors: insights from the anucleate platelet [PDF]

, 2018
Nuclear receptors have the ability to elicit two different kinds of responses, genomic and non-genomic. While genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of ...
Ahmadian, Ahuja, Ajayi, Ajjan, Akarasereenont, Akbiyik, Ali, Ali, Ali, Amanda J Unsworth, Badimon, Bain, Bar, Beckman, Bishop-Bailey, Bledsoe, Boilard, Boonyaratanakornkit, Borsig, Burris, Bye, Calkin, Campelo, Cecchetti, Cesario, Chinetti, Cumhur Cure, Dolle, Du, Duong, El Haouari, Evans, Falkenstein, Filippatos, Frye, Gabbi, Gagan D Flora, Ghasri, Güncü, Hammes, Hankey, Hellgren, Huang, Johnson, Johnson, Jonathan M Gibbins, Jones, Kadmiel, Kato, Kersten, Khan, Khetawat, Kiss, Krasowski, Kwon, Layton, Lee, Li, Liverani, Losel, Makishima, Matsuda, Maximov, McKenna, Mencarelli, Moraes, Moraes, Moraes, Moraes, Moraes, Morrell, Muchmore, Murphy, Nadal, Nathan, Ng, Njar, Noy, Ordóñez-Morán, Overington, Pilo, Richard, Risitano, Rondina, Rowley, Santilli, Sato, Schaffer, Schneider, Schubert, Schulz, Schwertz, Sepe, Sidhu, Silvagno, Spyridon, Sundahl, Trayhurn, Unsworth, Unsworth, Unsworth, Unsworth, Valera, Walmsley, Wang, Wu‐Wong, Wójcicka, Xu, Zimmerman   +108 more
core   +2 more sources

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice [PDF]

, 2017
The nuclear bile acid receptor FXR (farnesoid-X-receptor) has recently been implicated in the pathophysiology of non-alcoholic fatty liver disease because selective FXR-agonists improve glucose and lipid metabolism in rodent models of obesity.
Geier, Andreas, Martin, Ina V., Mertens, Joachim C., Minkenberg, Alexander, Mullhaupt, Beat, Schmitt, Johannes, Stieger, Bruno   +6 more
core  

Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. [PDF]

, 2017
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.In mammals, the pregnane X receptor (PXR) is a transcription factor with a key role in regulating expression of several genes involved in drug
Corcoran, J, Iguchi, T, Lange, A, Miyagawa, S, Tyler, CR, Winter, MJ   +5 more
core   +1 more source

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

Journal of Biological Chemistry, 2017
The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-protein receptor 5 (TGR5), are known to improve glucose and insulin sensitivity in obese and diabetic mice.
P. Pathak, Hailiang Liu, Shannon Boehme, Cen Xie, K. Krausz, F. Gonzalez, J. Chiang   +6 more
semanticscholar   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

Scientific Reports
Target identification is a crucial step in elucidating the mechanisms by which functional food components exert their functions. Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid ...
Chisato Tanaka, Naoki Harada, Yoshiaki Teraoka, Hiroki Urushizaki, Yoh Shinmori, Teruaki Onishi, Yusuke Yotsumoto, Yuta Ito, Tomoya Kitakaze, Takashi Inui, Yuji Murata, Hiroshi Inui, Ryoichi Yamaji   +12 more
doaj   +1 more source

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]

, 2014
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W, Hunter, Irene, Lavery, Derek N, MacKenzie, Alasdair, McEwan, Iain J, Watt, Kate   +5 more
core   +2 more sources

Correlation of Bile Acid Dynamics to Bulevirtide Response and Disease Severity in Patients With Hepatitis D

Alimentary Pharmacology &Therapeutics, EarlyView.
Bulevirtide increases bile acid levels in most patients; however, changes in bile acids do not predict virological response or adverse events, nor do they reflect treatment adherence. After discontinuation of bulevirtide, bile acid levels rapidly decline.
Marlene Hintersteininger, Michael Schwarz, Philipp Schwabl, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Georg Kramer, Christian Sebesta, Paul Thöne, Patrik Attalla, Michael Gschwantler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Mathias Jachs   +14 more
wiley   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source