Results 121 to 130 of about 53,933 (241)

Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

Frontiers in Pharmacology, 2012
The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR)
Petr ePavek, Lucie eStejskalova, Lucie eKrausova, Michal eBitman, Radim eVrzal, Zdenek eDvorak   +5 more
doaj   +1 more source

A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

Journal of Biological Chemistry, 2017
Even in healthy individuals, renal function gradually declines during aging. However, an observed variation in the rate of this decline has raised the possibility of slowing or delaying age-related kidney disease.
Xiaoxin X. Wang, Yuhuan Luo, Dong Wang, L. Adorini, M. Pruzanski, Evgenia Dobrinskikh, M. Levi   +6 more
semanticscholar   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

npj Metabolic Health and Disease
Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH).
Milton Boaheng Antwi, Ariann Jennings, Sander Lefere, Dorien Clarisse, Anja Geerts, Lindsey Devisscher, Karolien De Bosscher   +6 more
doaj   +1 more source

Allosteric modulation of the farnesoid X receptor by a small molecule

Scientific Reports, 2018
The bile acid activated transcription factor farnesoid X receptor (FXR) regulates numerous metabolic processes and is a rising target for the treatment of hepatic and metabolic disorders.
Matthias Gabler, Jan Kramer, Jurema Schmidt, Julius Pollinger, Julia Weber, Astrid Kaiser, Frank Löhr, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk   +9 more
doaj   +1 more source

GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo [PDF]

, 2015
We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner.
Amendola, Donatella, Avena, Paola, Campana, Carmela, Carpinelli, Giulia, Casaburi, Ivan, Cerquetti, Lidia, Chimento, Adele, De Luca, Arianna, Domanico, Francesco, Fallo, Francesco, Malivindi, Rocco, Martire, Emilia, Pezzi, Vincenzo, Rizza, Pietro, Sirianni, Rosa, Stigliano, Antonio, Zolea, Fabiana   +16 more
core   +2 more sources

Effects of Weight Loss Interventions on Gut Microbiota‐Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra, Leonardo André Swarowsky Loebens, Andrea Auler, Eduarda Caroline Tasso Nascimento, Beatriz D. Schaan, Patrícia Martins Bock   +5 more
wiley   +1 more source

Novel bile acid therapeutics for the treatment of chronic liver diseases

Therapeutic Advances in Gastroenterology, 2016
Recent developments in understanding the role of bile acids (BAs) as signalling molecules in human metabolism and inflammation have opened new avenues in the field of hepatology research.
Vinod S. Hegade, R. Alexander Speight, Rachel E. Etherington, David E. J. Jones   +3 more
doaj   +1 more source

Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.

PLoS ONE, 2011
BackgroundAdipocytes from mesenteric white adipose tissue amplify the inflammatory response and participate in inflammation-driven immune dysfunction in Crohn's disease by releasing proinflammatory mediators.
Andrea Mencarelli, Eleonora Distrutti, Barbara Renga, Claudio D'Amore, Sabrina Cipriani, Giuseppe Palladino, Annibale Donini, Patrizia Ricci, Stefano Fiorucci   +8 more
doaj   +1 more source

Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats [PDF]

, 2013
Background. Significant physiological changes occur during pregnancy and lactation. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease closely related to disruption of bile acid homeostasis.
Dan Zhang, Hong M. Xie, Jie Liu, Qiong N. Zhu, Yuan F. Lu   +4 more
core   +1 more source