Results 131 to 140 of about 53,933 (241)

Bile Acids and Farnesoid X Receptor: Novel Target for the Treatment of Diabetic Cardiomyopathy.

Current protein and peptide science, 2019
Diabetes mellitus (DM) has become an increasingly common disease with high disability and mortality rates. Diabetes complications are the main cause of diabetes death and about 50% of diabetic patients died from heart disease in developed countries ...
Chao Li, Yunlun Li, Z. Gai
semanticscholar   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS‐STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

Glia, Volume 74, Issue 6, June 2026.
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Esma I. Yerlikaya, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Clay T. Yeager, Kashif A. Shaikh, Edward W. Harhaj, Alistair J. Barber, Michael D. Dennis   +8 more
wiley   +1 more source

Regulation of human class I alcohol dehydrogenases by bile acids

Journal of Lipid Research, 2013
Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver. Because previous studies have shown that human ADH1 enzymes may participate in bile acid metabolism, we investigated whether
Cédric Langhi, Elena Pedraz-Cuesta, Diego Haro, Pedro F. Marrero, Joan C. Rodríguez   +4 more
doaj   +1 more source

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

, 2018
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P., Donaghy, Dillon, Gibbins, Jonathan M., Kriek, Neline, Osborne, Ashley A., Sage, Tanya, Unsworth, Amanda J.   +6 more
core   +4 more sources

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease

Digestive Diseases, 2017
Farnesoid X receptor (FXR) regulates the synthesis, transport and enterohepatic circulation of bile acids (BA) by modulating the expression of related genes in the liver and small intestine.
F. Gonzalez, Changtao Jiang, Cen Xie, A. Patterson   +3 more
semanticscholar   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase1

Journal of Lipid Research, 2006
We discovered a nuclear receptor element in the FAS promoter consisting of an inverted repeat spaced by one nucleotide (IR-1) and located 21 bases downstream of a direct repeat sequenced by 4 nucleotides (DR-4) oxysterol liver X receptor response element.
Karen E. Matsukuma, Mary K. Bennett, Jiansheng Huang, Li Wang, Gregorio Gil, Timothy F. Osborne   +5 more
doaj   +1 more source

Farnesoid X Receptor Signaling Activates the Hepatic X-box Binding Protein 1 Pathway in vitro and in Mice

Hepatology, 2018
Bile acids are endogenous ligands of the nuclear receptor, farnesoid X receptor (FXR), and pharmacological FXR modulators are under development for the treatment of several liver disorders.
Xiaoying Liu, G. Guo, Bo Kong, David B Hilburn, S. Hubchak, Seong-Nam Park, Brian E. LeCuyer, Antony Hsieh, Li Wang, Deyu Fang, R. Green   +10 more
semanticscholar   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, Volume 15, Issue 17, 8 May 2026.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Targeting farnesoid X receptor as aging intervention therapy

Acta Pharmaceutica Sinica B
Environmental toxicants have been linked to aging and age-related diseases. The emerging evidence has shown that the enhancement of detoxification gene expression is a common transcriptome marker of long-lived mice, Drosophila melanogaster, and ...
Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, Xinyi Wang, Hang Shi, Minglv Fang, Ying Liu, Young-Bum Kim, Huanhu Zhu, Xiaojun Wu, Cheng Huang, Shengjie Fan   +12 more
doaj   +1 more source