Results 151 to 160 of about 53,933 (241)

Epidemiology, Risk Factors and Pathophysiology of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: An Update

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin, Paul Henderson, Richard Pollok, Natália Queiroz, Luca Fabris, Edoardo Vincenzo Savarino, Iago Rodríguez‐Lago, Brigida Barberio   +7 more
wiley   +1 more source

Gut Microbiota as a Mediator of Sarcopenic Obesity: Mechanisms, Modifiable Factors, and Healthcare Burden

Molecular Nutrition &Food Research, Volume 70, Issue 10, 27 May 2026.
Sarcopenic obesity is closely associated with gut microbiota dysbiosis, chronic inflammation, oxidative stress, and impaired muscle metabolism. The gut–muscle–adipose axis is increasingly recognized as a key mechanism linking obesity and sarcopenia. Nutritional strategies, probiotics, prebiotics, postbiotics, and exercise may modulate gut microbiota ...
Mehtap Ünlü Söğüt, Merve Ahıskalı, Mina Mohammadzadeh, Menşure Nur Çelik, Nurcan Coşkun Us   +4 more
wiley   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Editorial: Nuclear receptors in hemodynamics and blood pressure control

Frontiers in Physiology, 2023
John D. Imig, Jing Wu, Jing Wu, Eman Y. Gohar   +3 more
doaj   +1 more source

Significant Reduction of Chenodeoxycholic Acid and Glycochenodeoxycholic Acid in the Elderly with Severe COVID-19

Biomolecules
Elderly individuals infected with SARS-CoV-2 are at higher risk of developing cytokine storms and severe outcomes, yet specific biomarkers remain unclear.
Shiyang Liu, Wen Xu, Bo Tu, Zhiqing Xiao, Xue Li, Lei Huang, Xin Yuan, Shengdong Luo, Juanjuan Zhou, Xinxin Yang, Junlian Yang, De Chang, Weiwei Chen, Fu-Sheng Wang   +13 more
doaj   +1 more source

A formação de HDL disfuncionais na diabetes mellitus e o risco cardiovascular [PDF]

, 2016
Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraAs diferentes funções protetoras das lipoproteínas de alta densidade (HDL), que
Figueiredo, João Luís da Silva
core  

Metabolic Regulation by Nuclear Receptors [PDF]

, 2015

core   +1 more source

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.

Molecular Endocrinology, 2007
Catia Marzolini, R. Tirona, G. Gervasini, B. Poonkuzhali, M. Assem, Wooin Lee, B. Leake, J. Schuetz, E. Schuetz, R. Kim   +9 more
semanticscholar   +1 more source

Activation of Brown Adipocytes by Farnesoid X Receptor Agonist, Obeticholic Acid-A Potential Novel Therapeutic Avenue in the Management of Obesity. [PDF]

J Clin Med
Dąbrowska AM, Chwil M, Urbańska EM.
europepmc   +1 more source