Results 101 to 110 of about 6,476 (207)

N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II [PDF]

, 2013
Recently a series of chiral N-(phenoxyalkyl)amides have been reported as potent MT(1) and MT(2) melatonergic ligands. Some of these compounds were selected and tested for their antioxidant properties by measuring their reducing effect against oxidation ...
A. Carocci, A. Catalano, A. De Palma, A. Lovece, C. Franchini, C. o. Bruno, F. De Santis, G. Lentini, ILLARIO, MADDALENA, M. G. Roselli, M. M. Cavalluzzi, M. R. Rusciano   +11 more
core   +1 more source

Chimeric melatonin mt1 and melatonin-related receptors. Identification of domains and residues participating in ligand binding and receptor activation of the melatonin mt1 receptor.

The Journal of biological chemistry, 2000
Melatonin receptors bind and become activated by melatonin. The melatonin-related receptor, despite sharing considerable amino acid sequence identity with melatonin receptors, does not bind melatonin and is currently an orphan G protein-coupled receptor.
S, Conway, J E, Drew, E S, Mowat, P, Barrett, P, Delagrange, P J, Morgan   +5 more
openaire   +1 more source

Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Melatonin is increasingly used to treat sleep disturbances, yet its overall efficacy remains unclear due to variability in existing evidence. This scoping review aimed to synthesize systematic reviews with meta‐analyses assessing the effects of exogenously administered melatonin on sleep quality in humans.
Samyuktha Iyer, Vaneesha Monk, Rebeccah Slater, Luke Baxter   +3 more
wiley   +1 more source

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source

Dianas terapéuticas de melatonina: propiedades y beneficios [PDF]

, 2018
La melatonina ( N - Acetil - 5 - metoxitriptamina ) es una hormona indólica derivada del triptófano, cuya producción ocurre principalmente en la glándula pineal. Está implicada en una gran cantidad de procesos biológicos pero su
Cid Galván, Nerea
core  

Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder [PDF]

, 2016
Loss of circadian rhythmicity fundamentally affects the neuroendocrine, immune and autonomic system, similar to chronic stress and may play a central role in the development of stress-related disorders.
Agorastos, Agorastos, Linthorst, Astrid C E   +1 more
core   +2 more sources

A Randomized, Triple‐Blind, Placebo‐Controlled, Parallel Clinical Trial Investigating Safety and Efficacy of Corn Leaf Extract on Sleep Quality in a Healthy Population With Difficulty Falling or Staying Asleep

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Corn leaf extract (CLE) contains a naturally occurring substance, 6‐methoxybenzoxazolinone (6‐MBOA). Structurally similar to melatonin, 6‐MBOA acts as a weak β‐adrenergic agonist with an affinity for melatonin receptors and stimulating melatonin synthesis.
Katarina M. Doma, Abdelrahman Zamzam, David C. Crowley, Najla Guthrie, Erin D. Lewis   +4 more
wiley   +1 more source

In-vivo Thermal Stress Induces Melatonin Receptors and Heat Shock Proteins Expression in the Spleen of Mice in a Time and Temperature Dependent Manner [PDF]

Journal of Stress Physiology & Biochemistry, 2023
Heat shock proteins (Hsps) responses against stress conditions. Melatonin completes its stress relieving activities via its MT1 and MT2 receptors. The present study delineates the expression pattern of Hsp70/Hsc70 and MT1/MT2 receptor proteins along with
Samik Acharjee, Shiv Shankar Singh
doaj  

Integrated Analysis of the Immune Infiltration Pattern and Novel Diagnostic Biomarkers in Septic Cardiomyopathy

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
In this study, various informatics analyses were employed to identify hub genes associated with the onset of septic cardiomyopathy and investigate its immune infiltration status. ABSTRACT Purpose In this study, various informatics analyses were employed to identify the hub genes associated with septic cardiomyopathy (SCM) onset and investigate their ...
Wei Liu, Xi Zheng, Dong Wang, Jingyi Wang, Xincheng Li, Fei Li, Wenxiong Li, Jin Zhang   +7 more
wiley   +1 more source

Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway [PDF]

Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland,
Boontem, Parichart, Govitrapong, Piyarat, Jenwitheesuk, Anorut, Mukda, Sujira, Tocharus, Jiraporn, Wongchitrat, Prapimpun   +5 more
core   +1 more source