The role of melatonin in mood disorders [PDF]
, 2015 Melatonin (N-acetyl-5-methoxytryptamine) has been discovered as a hormone secreted by the pineal gland, even though it is also synthetized in various other organs, tissues, and cells.
Cavuto, Marilde +14 more
core +1 more source
Remodeling Of The Bone Tissue Of Rats Of Different Lines After Melatonin Effect [PDF]
, 2016 The markers of remodeling of bone tissue (BT) were studied after the impact of pharmacologic dose of melatonin (5 mg/kg of the animal body weight) during 28 days for 3-months rats-males of Wistar and SHR lines.
Berezovskyi, V. (Vadim) +2 more
core +2 more sources
Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses
BMC Oral Health, 2020 Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong +2 more
doaj +1 more source
Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis [PDF]
, 2013 Seasonal mammalsintegrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendocrine ...
Burt, Dw +8 more
core +1 more source
Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function [PDF]
Science Signaling, 2013 Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
Baba, Kenkichi +11 more
openaire +3 more sources
Melatonin and Human Cardiovascular Disease [PDF]
, 2016 The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood ...
Akinseye, Oluwaseun A. +8 more
core +2 more sources
Melatonin Synergizes the Chemotherapeutic Effect of Cisplatin in Ovarian Cancer Cells Independently of MT1 Melatonin Receptors [PDF]
In Vivo, 2018 Melatonin (MLT), through the interaction with membrane melatonin receptors MT1, can improve the effectiveness of cytostatic agents, including cisplatin (CP). The aim of this study was to examine the synergistic effect of MLT and CP in three cell lines: IOSE 364, SK-OV-3 and OVCAR-3, as well as to assess the role of MT1 receptors in this mechanism.Using
Agata, Zemła +3 more
openaire +3 more sources
Neurobiology of Disease, 2013 Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage.
Yi Zhang +13 more
doaj +1 more source
Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes. [PDF]
PLoS ONE, 2014 The human melatonin MT1 receptor-belonging to the large family of G protein-coupled receptors (GPCRs)-plays a key role in circadian rhythm regulation and is notably involved in sleep disorders and depression.
Christel Logez +10 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang +4 more
wiley +1 more source