Results 81 to 90 of about 39,843 (183)

Following the Action of Atypical Antipsychotic Clozapine and Possible Prediction of Treatment Response in Schizophrenia

Life
We tried to synthesize the possibilities of predicting the response to clozapine treatment, which can significantly improve the efficacy of the active substance and reduce adverse reactions, and how the active substance acts at the D1 dopaminergic ...
Mihai-Gabriel Năstase, Antonia Ioana Vasile, Arina Cipriana Pietreanu, Simona Trifu   +3 more
doaj   +1 more source

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj   +1 more source

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Scientific Reports
The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and in silico studies. To assess the effect, doses of 50 mg/kg b.w. copper sulfate (CuSO4⋅5H2O) were given orally to 2-day-old chicks. The test compound
Rubel Hasan, Abdulrahman Alshammari, Norah A. Albekairi, Md. Shimul Bhuia, Meher Afroz, Raihan Chowdhury, Muhammad Ali Khan, Siddique Akber Ansari, Irfan Aamer Ansari, Mohammad S. Mubarak, Muhammad Torequl Islam   +10 more
doaj   +1 more source

From dopamine to muscarine: xanomeline-trospium (KarXT) as a novel direction in the psychopharmacotherapy of schizophrenia. [PDF]

Front Pharmacol
Żełabowski K, Pichowicz W, Dembowska J, Szwajkowski M, Mykhailova D, Wurm G, Biedka K, Błaszczyk K, Piotrowski P.   +8 more
europepmc   +1 more source

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

P2‐207: Discovery of a highly M5‐preferring muscarinic acetylcholine receptor allosteric potentiator [PDF]

Alzheimer's & Dementia, 2009
Thomas M. Bridges, Joy E. Marlo, Colleen M. Niswender, Patrick R. Gentry, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley   +6 more
openaire   +1 more source

Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)‐Selective M5‐Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe

ChemMedChem, 2014
P. Gentry, M. Kokubo, T. Bridges, Hyekyung P. Cho, Emery Smith, P. Chase, P. Hodder, T. Utley, A. Rajapakse, Frank W. Byers, C. Niswender, R. Morrison, J. Daniels, M. Wood, P. Conn, C. Lindsley   +15 more
semanticscholar   +1 more source

Modulation of Master Transcription Factor Expression of Nile Tilapia Leukocytes via Cholinergic Pathways. [PDF]

Int J Mol Sci
Girón-Pérez MI, Ramírez-Ibarra KM, Covantes-Rosales CE, Girón-Pérez DA, Razura-Carmona FF, Contis-Montes de Oca A, Morales-Montor J, Pavón L, Toledo-Ibarra GA.   +8 more
europepmc   +1 more source