Results 151 to 160 of about 12,430 (191)

Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter

Neuroscience Letters, 1999
The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT.
Rioux, Agnès, Fabre, Véronique, Peter Lesch, K, Moessner, Rainald, Murphy, Dennis, Lanfumey, Laurence, Hamon, Michel, Martres, Marie-Pascale   +7 more
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Serotonin 5-HT2A Receptors: Molecular Biology and Mechanisms of Regulation

Critical Reviews™ in Neurobiology, 1998
Serotonin 5-HT2A receptors are essential for a large number of physiological functions in the central nervous system and periphery. This review article summarizes our current knowledge of the molecular biology and mechanisms of regulation of 5-HT2A receptors.
B L, Roth, S A, Berry, W K, Kroeze, D L, Willins, K, Kristiansen   +4 more
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No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism [PDF]

Psychiatry Research, 1997
The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene for bipolar affective disorder (BPAD)
Mahieu, Brigitte, Souery, Daniel, Lipp, Olivier, Mendelbaum, Karine, Verheyen, Geert R., De Maertelaer, Viviane, Van Broeckhoven, Christine, Mendlewicz, Julien   +7 more
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Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals

European Archives of Psychiatry and Clinical Neuroscience, 2022
Antisocial behavior (ASB) is characterized by frequent violations of the rights and properties of others, as well as aggressive conduct. While ample evidence points to a critical role of serotonin in the emotional modulation of social responses, the implication of this neurotransmitter in ASB is unclear.
Braccagni G., Scheggi S., Bortolato M.
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EMD 281014, a new selective serotonin 5-HT2A receptor antagonist

European Journal of Pharmacology, 2003
The 5-HT2A receptor ligand 7-[4-[2-(4-fluoro-phenyl)-ethyl]-piperazine-1-carbonyl]-1H-indole-3-carbonitrile HCl (EMD 281014) selectively binds to human (h) and rat 5-HT2A receptors (IC50 values 0.35 and 1 nM, respectively; vs. 1334 nM for h5-HT2C) and inhibited 5-HT-stimulated [35S]guanosine 5'-O-3-thiotriphosphate (GTPgammaS)-accumulation in h5-HT2A ...
Gerd D, Bartoszyk, Christoph, van Amsterdam, Henning, Böttcher, Christoph A, Seyfried   +3 more
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Strategies for mapping the binding site of the serotonin 5-HT2A receptor

2002
Publisher Summary The serotonin 5-HT2A receptor is a member of the G protein-coupled receptor (GPCR) superfamily for which studies have identified key interactions in the ligand–receptor complexes. To overcome the limitations inherent in both site-directed mutagenesis and computational modeling, mutational experiments and computational techniques ...
Barbara J, Ebersole, Stuart C, Sealfon
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Biochemical Localisation of the 5-HT2A(serotonin) Receptor in Rat Skeletal Muscle

Biochemical and Biophysical Research Communications, 1999
The 5-HT2A receptor was recently shown to localise morphologically to the transverse tubules (TT) in rat foetal myoblasts. Receptor activation enhanced the expression of genes involved in myogenesis, and its TT localisation has led to the suggestion that it may participate in excitation-contraction coupling.
E, Hajduch, L, Dombrowski, F, Darakhshan, F, Rencurel, A, Marette, H S, Hundal   +5 more
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Glucocorticoid treatment increases density of serotonin 5-HT2A receptors in humans

Psychoneuroendocrinology, 2013
Interactions between the serotonergic system and the hypothalamic-pituitary-adrenal axis have been suggested, albeit the details for such interactions have yet to be established. Animal studies have shown that the density of serotonin 5-HT2A receptors is increased after administration of exogenous glucocorticoids.The objective of this study was to ...
Anders, Kling, Tom, Mjörndal, Solbritt, Rantapää-Dahlqvist   +2 more
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Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists

Drugs, 2020
Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol's
Michael, Poyurovsky, Abraham, Weizman
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Headache may be caused by activation of 5-HT2A receptors in serotonin toxicity

BMJ, 2014
Buckley and colleagues discuss the serotonin syndrome.1 Hunter serotonin toxicity criteria include neuromuscular hyperactivity, autonomic hyperactivity, and altered mental state.2 Mild symptoms of serotonin toxicity can be …
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