Results 171 to 180 of about 12,430 (191)

Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT2A receptors

Pharmacological Reports, 2019
There is a strong support for the role of serotonin (5-HT) neurotransmission in depression and in the mechanism of action of antidepressants. Among 5-HT receptors, 5-HT2A receptor subtype seems to be an important target implicated in the above disorder.The aim of the study was to investigate the effects of antidepressants, such as imipramine (15 mg/kg),
Dawid, Gawliński, Irena, Smaga, Magdalena, Zaniewska, Kinga, Gawlińska, Agata, Faron-Górecka, Małgorzata, Filip   +5 more
openaire   +2 more sources

Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain

Neuroscience Letters, 2007
Chronic thyroxine administration (2.0 mg/l, 60 days) significantly increases the 5-HT2A serotonin receptor gene mRNA level in the frontal cortex and augments the frequency of head twitches induced by the receptor agonist DOI (1.0 mg/kg, i.p.) in AKR mice. The result indicates thyroid hormones involvement in 5-HT2A receptor regulation in adult brain.
A V, Kulikov, E A, Zubkov
openaire   +2 more sources

5-HT2A receptor subtype is involved in the thermal hyperalgesic mechanism of serotonin in the periphery

Pain, 1998
The present study was designed to investigate which subtypes of 5-HT receptors are involved in 5-HT-induced hyperalgesia using behavioral assessment of hyperalgesia. 5-HT and various putative agonists for 5-HT receptor subtypes (5-HT(1A, 2, 3)) were intradermally injected into the rat ipsilateral hindpaw.
Atsushi, Tokunaga, Misako, Saika, Emiko, Senba   +2 more
openaire   +2 more sources

Distribution of serotonin 5‐HT2A receptors in afferents of the rat striatum

Synapse, 2001
Treatment with conventional antipsychotic drugs (APDs) is accompanied by extrapyramidal side effects (EPS), which are thought to be due to striatal dopamine D(2) receptor blockade. In contrast, treatment with atypical APDs is marked by a low incidence or absence of EPS.
M, Bubser, J R, Backstrom, E, Sanders-Bush, B L, Roth, A Y, Deutch   +4 more
openaire   +2 more sources

Targeting serotonin 5-HT2A receptors in the treatment of aggression: From antipsychotics to psychedelics

Aggression and Violent Behavior
Aggression, anger, and irritability emerge from dysregulated interactions between prefrontal and limbic circuits, with serotonin (5-HT) exerting a central regulatory influence. Among serotonergic targets, the 5-HT2A receptor has emerged as a key modulator of aggressive behavior.
Scheggi S., Braccagni G., Branca C., Bortolato M.   +3 more
openaire   +2 more sources

A Complex Impact of Systemically Administered 5-HT2A Receptor Ligands on Conditioned Fear

International Journal of Neuropsychopharmacology, 2021
Robert Pettersson, Jakob Näslund, Elias Eriksson   +2 more
exaly  

Role of Striatal Serotonin2A and Serotonin2C Receptor Subtypes in the Control of In Vivo Dopamine Outflow in the Rat Striatum

Journal of Neurochemistry, 2001
Guillaume Lucas, Umberto Spampinato
exaly  

Serotonin2C Receptors and Serotonin2C Receptor-Mediated Phosphoinositide Hydrolysis in the Brain of Alcohol-Preferring and Alcohol-Nonpreferring Rats

Alcoholism: Clinical and Experimental Research, 1996
Subhash C Pandey, Lawrence Lumeng, T -K Li   +2 more
exaly  

Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors

Journal of Neurochemistry, 2006
Sylvia Navailles, Dimitri Ryczko, Umberto Spampinato   +2 more
exaly  

5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum

Neuropsychopharmacology, 2001
Vincenzo Di Matteo, Claudia Fracasso, Guillaume Lucas   +2 more
exaly