Results 91 to 100 of about 2,320,796 (216)

TrkA receptors delay C6-2B glioma cell growth in rat striatum

Molecular Brain Research, 1998
Nerve growth factor (NGF) acts as an anti-mitogenic factor in C6-2B glioma cells stably expressing TrkA (C6trk+). To study the effect of TrkA on cell growth in vivo, we grafted mock and C6trk+ cells into the striatum of ACI nude rats. Thy 1.1 and p75NTR immunohistochemistry revealed that wild type C6-2B cells formed a tumor mass in the striatum by 14 ...
S J, Rabin, C, Tornatore, B, Baker-Cairns, G, Spiga, I, Mocchetti   +4 more
openaire   +2 more sources

The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor

Frontiers in Neuroscience, 2016
The nerve growth factor (NGF) N-terminus peptide, NGF(1–14), and its acetylated form, Ac-NGF(1–14), were investigated to scrutinize the ability of this neurotrophin domain to mimic the whole protein.
G. Pandini, C. Satriano, Adriana Pietropaolo, F. Gianì, Alessio Travaglia, D. La Mendola, V. Nicoletti, E. Rizzarelli   +7 more
semanticscholar   +1 more source

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

Annals of the Rheumatic Diseases, 2015
Objectives Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain.
L. Nwosu, P. Mapp, V. Chapman, D. Walsh
semanticscholar   +1 more source

THE RATIO OF TrkA AND p75 RECEPTORS ON THE CELL NEUROEPITHELIAL TUMORS – A NEW TARGET EFFECT OF NERVE GROWTH FACTOR WITH CISPLATIN AND TEMOZOLOMIDE AND THE COMBINATIONS

Опухоли головы и шеи, 2017
Objective. To study the change of expression of TrkA, p75 receptors and their ratio on the human anaplastic astrocytoma, glioblastoma and medulloblastoma cells cultures exposed to nerve growth factor (NGF) and its combination with cisplatin or ...
A. N. Chernov
doaj   +1 more source

Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

Scientific Reports, 2018
Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
doaj   +1 more source

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Journal of Experimental & Clinical Cancer Research, 2018
Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA ...
Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli, Andrew Reay Mackay   +6 more
doaj   +1 more source

Tissue-specific alternative splicing generates two isoforms of the trkA receptor

Journal of Biological Chemistry, 1993
The trkA receptor functions as a signal transducing receptor for nerve growth factor. In this report, we show that alternative splicing results in the production of two distinct trkA isoforms in both rats and humans. These isoforms differ by virtue of a 6-amino acid insertion in their extracellular domain, the placement of which corresponds exactly ...
P A, Barker, C, Lomen-Hoerth, E M, Gensch, S O, Meakin, D J, Glass, E M, Shooter   +5 more
openaire   +2 more sources

A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice

Journal of Pharmacological Sciences, 2010
Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma, Eri Murata, Koyo Ueda, Yoshihiro Kuroda, Ming-Hui Cao, Mineo Abe, Kenji Shigemi, Munetaka Hirose   +7 more
doaj   +1 more source

Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases

Pharmaceuticals
Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases.
George N. Chaldakov, Luigi Aloe, Stanislav G. Yanev, Marco Fiore, Anton B. Tonchev, Manlio Vinciguerra, Nikolai T. Evtimov, Peter Ghenev, Krikor Dikranian   +8 more
doaj   +1 more source

Mast cell activation by NGF drives the formation of trauma-induced heterotopic ossification

JCI Insight
Soft tissue trauma can cause immune system disturbance and neuropathological invasion, resulting in heterotopic ossification (HO) due to aberrant chondrogenic differentiation of mesenchymal stem cells (MSCs).
Tao Jiang, Xiang Ao, Xin Xiang, Jie Zhang, Jieyi Cai, Jiaming Fu, Wensheng Zhang, Zhenyu Zheng, Jun Chu, Minjun Huang, Zhongmin Zhang, Liang Wang   +11 more
doaj   +1 more source