Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 2001 Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase [PDF]
, 2003 Nerve growth factor (NGF) mediates the survival and differentiation of neurons by stimulating the tyrosine kinase activity of the TrkA/NGF receptor. Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA.
Dubreuil, Catherine I. +13 more
core +2 more sources
Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice
iScience, 2023 Summary: In mature bone, NGF is produced by osteoblasts following mechanical loading and signals through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), to support bone formation.
Ibtesam Rajpar +3 more
doaj
In VivoRegulation of NGF-Mediated Functions by Nedd4-2 Ubiquitination of TrkA [PDF]
, 2014 [EN]Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors.However,the in vivo consequences of Trk ubiquitination remainto be addressed.We have developed a mouse model ...
Anta Rodríguez, Begoña +8 more
core +1 more source
Dynamics of cooperativity in chemical sensing among cell-surface receptors [PDF]
, 2011 Cooperative interactions among sensory receptors provide a general mechanism to increase the sensitivity of signal transduction. In particular, bacterial chemotaxis receptors interact cooperatively to produce an ultrasensitive response to chemoeffector concentrations.
arxiv +1 more source
Tyrosine kinase A, C and fibroblast growth factor-2 receptors in bovine embryos cultured in vitro [PDF]
, 2009 Neurotrophins and basic fibroblast growth factor are ligands of tyrosine kinase receptors, though they bind to different tyrosine kinase receptor classes.
Caamaño, J. N. +8 more
core
The Trk Potassium Transporter Is Required for RsmB-Mediated Activation of Virulence in the Phytopathogen Pectobacterium wasabiae [PDF]
, 2015 Pectobacterium wasabiae (previously known as Erwinia carotovora) is an important plant pathogen that regulates the production of plant cell wall-degrading enzymes through an N-acyl homoserine lactone-based quorum sensing system and through the GacS/GacA ...
Valente, Rita S., Xavier, Karina Bivar
core +1 more source
Receptor arrays optimized for natural odor statistics [PDF]
, 2016 Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an information-theoretic model, we show that a receptor array is optimal for this task if it achieves two possibly conflicting goals ...
arxiv +1 more source
Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]
, 2015 The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA +2 more
core +2 more sources
Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes [PDF]
Acentral tenet of nerve growth factor (NGF) action that is poorly understood is its ability to mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve terminal and conveyed to the soma.
Akmentin, Wendy +7 more
core +2 more sources