Results 11 to 20 of about 59,132 (205)

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE) [PDF]

Journal of Clinical Investigation, 2001
Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with decline in renal function. The underlying pathogenic link between chronic hyperglycemia and the development of tubulointerstitial injury has not been fully elucidated, but myofibroblast formation represents a key step in the development of tubulointerstitial ...
Oldfield, MD, Bach, LA, Forbes, JM, Nikolic-Paterson, D, McRobert, A, Thallas, V, Atkins, RC, Osicka, T, Jerums, G, Cooper, ME   +9 more
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Receptor for Advanced-Glycation End Products [PDF]

Circulation, 2006
Background— The beneficial effects of reperfusion therapies have been limited by the amount of ischemic damage that occurs before reperfusion. To enable development of interventions to reduce cell injury, our research has focused on understanding mechanisms involved in cardiac cell death after ...
Bucciarelli L, Kaneko M, Ananthakrishnan R, Harja E, Lee LK, Hwang YC, Lerner S, Bakr S, Li Q, Lu Y, Song F, Qu W, Gomez T, Zou YS, Yan SF, Schmidt AM, Ramasamy R   +16 more
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Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Frontiers in Endocrinology, 2022
Atherosclerosis (AS) is a chronic inflammatory disease and leading cause of cardiovascular diseases. The progression of AS is a multi-step process leading to high morbidity and mortality. Hyperglycemia, dyslipidemia, advanced glycation end products (AGEs)
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao   +3 more
doaj   +1 more source

Advanced Glycation End Product Recognition by the Receptor for AGEs [PDF]

Structure, 2011
Nonenzymatic protein glycation results in the formation of advanced glycation end products (AGEs) that are implicated in the pathology of diabetes, chronic inflammation, Alzheimer's disease, and cancer. AGEs mediate their effects primarily through a receptor-dependent pathway in which AGEs bind to a specific cell surface associated receptor, the ...
Xue, Jing, Rai, Vivek, Singer, David, Chabierski, Stefan, Xie, Jingjing, Reverdatto, Sergey, Burz, David S., Schmidt, Ann Marie, Hoffmann, Ralf, Shekhtman, Alexander   +9 more
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Prevention of Protein Glycation by Natural Compounds [PDF]

, 2015
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan.
Bartosz, Grzegorz, Sadowska-Bartosz, Izabela   +1 more
core   +5 more sources

Reduced soluble receptor for advanced glycation end-products in COPD [PDF]

European Respiratory Journal, 2010
The soluble receptor for advanced glycation end-products (sRAGE) has anti-inflammatory properties, and deficiency of circulating sRAGE is associated with various human diseases. Whether sRAGE concentrations are reduced in chronic obstructive pulmonary disease (COPD) has not been determined.
Smith, D. J., Yerkovich, S. T., Towers, M. A., Carroll, M. L., Thomas, R., Upham, J. W.   +5 more
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Pathological Role of Receptor for Advanced Glycation End Products in Calcified Aortic Valve Stenosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Aortic stenosis (AS) is highly prevalent in patients with atherosclerotic cardiovascular disease. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play a pivotal role for vascular calcification in atherosclerosis.
Kosuke Saku, Nobuhiro Tahara, Tohru Takaseya, Hiroyuki Otsuka, Kazuyoshi Takagi, Takahiro Shojima, Yusuke Shintani, Yasuyuki Zaima, Satoshi Kikusaki, Tomofumi Fukuda, Atsunobu Oryoji, Yuri Nishino, Takanori Matsui, Tatsuyuki Kakuma, Jun Akiba, Yoshihiro Fukumoto, Sho‐ichi Yamagishi, Hiroyuki Tanaka   +17 more
doaj   +1 more source

Receptor for advanced glycation end‐products: Biological significance and imaging applications

WIREs Nanomedicine and Nanobiotechnology, 2023
AbstractThe receptor for advanced glycation end‐products (RAGE or AGER) is a transmembrane, immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse range of endo‐ and exogenous ligands. RAGE activation caused by the ligand binding initiates a cascade of complex pathways associated with producing free radicals, such
Iwona T. Dobrucki, Angelo Miskalis, Michael Nelappana, Catherine Applegate, Marcin Wozniak, Andrzej Czerwinski, Leszek Kalinowski, Lawrence W. Dobrucki   +7 more
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Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]

, 2018
The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A, Currier, Judith S, Danoff, Ann, Kelesidis, Theodoros, Kendall, Michelle A, Schmidt, Ann Marie   +5 more
core   +1 more source

Advanced Glycation End Products and Receptor for Advanced Glycation End Products in AA Amyloidosis

The American Journal of Pathology, 2003
Advanced glycation end products (AGEs) may be involved in either amyloidogenesis or complications related to amyloid. We hypothesized that AGEs may influence the pathogenesis of AA amyloidosis, and investigated the spatial and temporal relationship between AGEs, carboxy methyl lysine (CML), the AGE receptor (RAGE), and AA amyloid in humans and mice ...
Christoph, Röcken, Rosemarie, Kientsch-Engel, Sophie, Mansfeld, Barbara, Stix, Kay, Stubenrauch, Bernd, Weigle, Frank, Bühling, Mona, Schwan, Wolfgang, Saeger   +8 more
openaire   +3 more sources