Results 21 to 30 of about 78,662 (379)

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury [PDF]

Biochemical Journal, 2003
Hideto Yonekura, Yasuhiko Yamamoto, Shigeru Sakurai, Ralica G Petrova, Md. Joynal Abedin, Hui Li, Kiyoshi Yasui, Masayoshi Takeuchi, Zenji Makita, Shin Takasawa, Hiroshi Okamoto, Takuo Watanabe, Hiroshi Yamamoto   +12 more
openalex   +2 more sources

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE) [PDF]

Journal of Clinical Investigation, 2001
Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with decline in renal function. The underlying pathogenic link between chronic hyperglycemia and the development of tubulointerstitial injury has not been fully elucidated, but myofibroblast formation represents a key step in the development of tubulointerstitial ...
Matthew D. Oldfield, Leon A. Bach, Josephine M. Forbes, David J. Nikolic‐Paterson, Anne McRobert, Vicki Thallas, Robert C. Atkins, Tanya M. Osicka, George Jerums, Mark E. Cooper   +9 more
openalex   +5 more sources

The biology of the receptor for advanced glycation end products and its ligands

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
Receptor for advanced glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules whose repertoire of ligands includes advanced glycation end products (AGEs), amyloid fibrils, amphoterins and S100/calgranulins.
Ann Marie Schmidt, Shi Du Yan, Shi Fang Yan, David M. Stern   +3 more
openalex   +4 more sources

The effect of Galega officinalis L. extract on the content of the advanced glycation end products and their receptors in rat leukocytes under experimental diabetes mellitus

Біологічні студії, 2021
Background. Diabetes mellitus intensifies non-enzymatic glycosylation (glycation) of biomolecules under conditions of chronic hyperglycemia and facilitates accumulation of advanced glycation end products.
Kh. Ye. Furtak, H. Ya. Hachkova, N. O. Sybirna   +2 more
doaj   +1 more source

Expression of advanced glycation end products and receptors in gingival tissues of patients with noninsulin-dependent diabetes mellitus-associated periodontitis

Journal of Dental Sciences, 2023
Background/purpose: Advanced glycation end products (AGEs) are known to accumulate in the periodontal tissues of patients with diabetes mellitus (DM). Through this study, we aimed to investigate the distribution of AGEs and the receptor of AGEs (RAGE) in
Ya-Han Chang, Chen-Ling Huang, An-Tsz Hsieh, Chia-Ai Jao, Hsein-Kun Lu   +4 more
doaj   +1 more source

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Translational Oncology, 2022
The molecular implications of food consumption on cancer etiology are poorly defined. The rate of nutrition associated non-enzymatic glycoxidation, a reaction that occurs between reactive carbonyl groups on linear sugars and nucleophilic amino, lysyl and
Bradley A. Krisanits, Pamela Woods, Lourdes M. Nogueira, Demarcus D. Woolfork, Courtney E. Lloyd, Andrew Baldwin, Callan C. Frye, Kendell D. Peterson, Sean D. Cosh, Qi-Jin Guo, Laura S. Spruill, Michael B. Lilly, Kristi Helke, Hong Li, George S. Hanna, Mark T. Hamann, Courtney Thomas, Mahtabuddin Ahmed, Monika B. Gooz, Victoria J. Findlay, David P. Turner   +20 more
doaj   +1 more source

Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism

International Journal of Molecular Sciences, 2023
Advanced glycation end products (AGEs) are mediators in the process of cellular dysfunction in response to hyperglycemia. Numerous data indicate that the accumulation of AGEs in the extracellular matrix plays a key role in the development of obesity ...
Klaudia Gutowska, K. Czajkowski, A. Kuryłowicz   +2 more
semanticscholar   +1 more source

The Role of Advanced Glycation End Products in Diabetic Vascular Complications [PDF]

Diabetes & Metabolism Journal, 2018
In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues.
Sang Youl Rhee, Young Seol Kim
doaj   +1 more source

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia [PDF]

JAMA Network Open, 2021
Advanced glycation end products (AGEs) and their receptor (RAGE) are implicated in the pathophysiological processes of dementia and potentially underlie the association of diabetes with neurodegeneration. However, longitudinal studies examining this association are lacking.To determine whether markers of the AGE-RAGE system are associated with ...
Komal Waqas, Jinluan Chen, André G. Uitterlinden, M. Kamran Ikram, Silvan Licher, Sanne S. Mooldijk, M. Carola Zillikens, M. Arfan Ikram   +7 more
openaire   +3 more sources

Advanced Glycation End Product Recognition by the Receptor for AGEs [PDF]

Structure, 2011
Nonenzymatic protein glycation results in the formation of advanced glycation end products (AGEs) that are implicated in the pathology of diabetes, chronic inflammation, Alzheimer's disease, and cancer. AGEs mediate their effects primarily through a receptor-dependent pathway in which AGEs bind to a specific cell surface associated receptor, the ...
David Singer, Stefan Chabierski, Ralf Hoffmann, Alexander Shekhtman, Jing Xue, Jingjing Xie, Sergey Reverdatto, Vivek Rai, Ann Marie Schmidt, David S. Burz   +9 more
openaire   +3 more sources