Results 201 to 210 of about 104,105 (242)

Angiotensin receptors

Trends in Pharmacological Sciences, 1997
The octapeptide angiotensin II, the potent effector molecule of the renin-angiotensin system, has been implicated in the pathology of hypertension, in cardiovascular diseases like cardiac left ventricular hypertrophy and in structural alterations of the heart such as post-infarct remodelling.The development of highly selective angiotensin II receptor ...
T, Unger, O, Chung, T, Csikos, J, Culman, S, Gallinat, P, Gohlke, S, Höhle, S, Meffert, M, Stoll, U, Stroth, Y Z, Zhu   +10 more
openaire   +3 more sources

Angiotensin Receptors - Affinity and Beyond

Clinical Science, 2022
Abstract This commentary on the article “Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors” by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297–303. https://doi.org/10.1042/CS20110036) summarises the main findings of the study, followed by a discussion of the findings and their relevance for
Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings   +2 more
openaire   +3 more sources

Angiotensin II Receptor Heterogeneity

American Journal of Hypertension, 1991
The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of our earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes.
William F. Herblin, Andrew T. Chiu, Dale E. McCall, Robert J. Ardecky, David J. Carini, John V. Duncia, Lori J. Pease, Pancras C. Wong, Ruth R. Wexler, Alexander L Johnson, Pieter B.M.W.M. Timmermans   +10 more
openaire   +2 more sources

Human angiotensin receptor subtypes

Current Opinion in Nephrology and Hypertension, 1994
The rapid expansion of our knowledge of angiotensin receptors has been led by the development of subtype-specific angiotensin II receptor antagonists and by the cloning and sequencing of the AT1 receptor in angiotensin II. Although some actions of angiotensin II have been attributed to AT2 subtype receptors, the importance of these binding sites ...
Ronald D. Smith, &NA; Pieter, &NA; Timmermans   +2 more
openaire   +2 more sources

Tachyphylaxis and angiotensin receptors

General Pharmacology: The Vascular System, 1976
Angiotensin tachyphylaxis was studied in the isolated guinea pig ileum under isometric conditions. 2. In tachyphylactic organs, the initial phasic response to angiotensin was abolished, while the tonic component of the response became faster in its onset and in its reversal (relaxation). 3.
Paiva, T. B., Aboulafia, J., Nouailhetas, VLA, Paiva, ACM   +3 more
openaire   +3 more sources

Angiotensin II Receptor Subtypes

American Journal of Hypertension, 1992
The octapeptide, angiotensin II (Ang II), the biologically active component of the renin-angiotensin system, elicits its multiple actions through the stimulation of specific surface receptors on various target organs. Although the existence of Ang II receptor subtypes has been suspected for some time, definitive evidence for Ang II receptor ...
P B, Timmermans, A T, Chiu, W F, Herblin, P C, Wong, R D, Smith   +4 more
openaire   +2 more sources

Angiotensin II receptor antagonists

The Lancet, 2000
Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors.
M, Burnier, H R, Brunner
openaire   +2 more sources

Angiotensin and angiotensin receptors in cartilaginous fishes

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001
In mammals, a principal bioactive component of the renin-angiotensin system (RAS), angiotensin II (ANG II), is known to be vasopressor, dipsogenic, a stimulant of adrenocortical secretion and to control glomerular and renal tubular function. Historically, a RAS analogous to that found in mammals was thought to have first evolved in the bony fishes ...
ANDERSON W. G, CERRA, Maria Carmela, WELLS A., TIERNEY M. L., TOTA B., TAKEI Y., HAZON . N.   +6 more
openaire   +3 more sources