Results 191 to 200 of about 132,216 (243)

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

Nature, 1989
THE T-cell repertoire within an individual is biased to recognize antigen in the context of self major histocompatibility complex (MHC) antigens. This is thought to depend on a process of positive selection during development. Support for this notion has recently been obtained in experiments using transgenic mice bearing genes for T-cell receptors (TCR)
B, Scott, H, Blüthmann, H S, Teh, H, von Boehmer   +3 more
openaire   +2 more sources

Depletion of mouse alpha beta T cell antigen receptor bearing lymphocytes by neonatal monoclonal antibody treatment

The Journal of Immunology, 1991
Abstract Neonatal treatment with a monoclonal antibody specific for the alpha beta TCR results in mice with a long term, severe depletion in the number of alpha beta T cells in the periphery. Significant numbers of T cells reappear in the periphery about age 65 days, but these cells tend to lack expression of CD4 or CD8.
P F, Mixter, B C, Sydora, R M, Hershberg, M, Kronenberg   +3 more
openaire   +2 more sources

Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta + and gamma delta+ human T cell clones isolated in IL-4.

The Journal of Immunology, 1989
Abstract IL-4 has been shown to act as a growth factor for human T cells. In addition, IL-4 can enhance CTL activity in MLC, but blocks IL-2 induced lymphokine activated killer cell activity in PBL. In our study, the cloning efficiencies, Ag-specific CTL activity and non-MHC-restricted cytotoxicity of CTL clones generated in IL-2 were
Paliard, X., Yssel, H., Blanchard, D., Waitz, J. A., deVries, J. E., Spits, H.   +5 more
openaire   +3 more sources

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage

The Journal of Immunology, 1991
Abstract We have characterized CD4-CD8- double negative (DN) thymocytes that express TCR-alpha beta and represent a minor thymocyte subpopulation expressing a markedly skewed TCR repertoire. We found that DN TCR-alpha beta + thymocytes resemble mature T cells in that they (a) are phenotypically CD2hiCD5hiQa2+HSA-, (b) appear late in ...
Y, Takahama, A, Kosugi, A, Singer
openaire   +2 more sources

Alloantigen-specific cytotoxic clones bearing the alpha,beta T cell antigen receptor but not CD4 or CD8 molecules.

The Journal of Immunology, 1990
Abstract The vast majority of circulating lymphocytes that express the alpha,beta TCR in association with CD3 also express either CD4 or CD8 molecules, which are thought to act as important accessory structures in HLA class II- and I-restricted T cell functions, respectively.
A, Rivas, J, Koide, R, Laus, E G, Engleman   +3 more
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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Nature, 1988
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens ...
H S, Teh, P, Kisielow, B, Scott, H, Kishi, Y, Uematsu, H, Blüthmann, H, von Boehmer   +6 more
openaire   +2 more sources

Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.

The Journal of Immunology, 1990
Abstract We have examined the expression of TCR genes in 4-hydroxy-3-nitrophenyl-acetyl (NP)-specific Ts cell hybridomas. Each of three independently isolated hybridomas expressed in-frame TCR alpha-chain rearrangements derived from the original suppressor Ts cell. Different V alpha and J alpha gene segments were rearranged and expressed
M, Collins, V K, Kuchroo, M J, Whitters, R M, O'Hara, K, Kelleher, R T, Kubo, M E, Dorf   +6 more
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Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex.

The Journal of Immunology, 1990
Abstract Eight different Ts cell hybridomas (including inducer (Ts1) and effector (Ts3) suppressor cells) specific for the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten were tested for their ability to respond to Ag or anti-CD3 antibody in a growth-inhibition assay. Results suggest that the expression of the TCR-CD3 complex on Ts hybridomas
V K, Kuchroo, P R, Billings, C, Levine, C A, Martin, R T, Kubo, M E, Dorf   +5 more
openaire   +2 more sources

A Subset of Splenic Macrophages Process and Present Native Antigen to Naive Antigen-Specific CD4+T-Cells from Mice Transgenic for an αβ T-Cell Receptor

Cellular Immunology, 1995
The progeny of individual macrophage precursors from mouse spleen were examined for their ability to constitutively process and present native pigeon cytochrome c or a peptide fragment of this antigen to naive CD4+ T-cells from mice transgenic for a V alpha 11/V beta 3 TCR that recognizes an epitope in the antigen fragment.
D, Askew, J, Gatewood, E, Olivas, K, Havenith, W S, Walker   +4 more
openaire   +2 more sources

Suppression of chronic antigen-induced arthritis in rats by a monoclonal antibody against the T cell receptor αβ

Cellular Immunology, 1992
We have investigated a role for T cells in chronic antigen-induced arthritis in rats employing a monoclonal antibody (R73 mAb) against the T cell receptor alpha beta. Treatment with R73 mAb from the time of intra-articular antigenic challenge blocked completely the induction of chronic, but not acute ovalbumin-induced arthritis in sensitized rats ...
S, Yoshino, J, Yoshino
openaire   +2 more sources