Results 221 to 230 of about 242,999 (280)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Frontiers of cytokine engineering in CAR cell therapy for cancer. [PDF]

Front Oncol
Wu Y, Li YR.
europepmc   +1 more source

Immune imbalance between T helper 1, T helper 17 and regulatory T cells fuels amyotrophic lateral sclerosis pathogenesis: disease trajectory, diagnosis and therapeutic implications. [PDF]

J Neuroinflammation
Sligar C, Sluyter R, Ooi L.
europepmc   +1 more source

Identification of HLA class II-restricted T cell receptors against shared PIK3CA mutations in patients with epithelial cancers. [PDF]

Cancer Immunol Immunother
Islam SMR, Seitter S, Parkhurst M, Lowery FJ, Fukuhara M, Kim SP, Levin N, Gartner JJ, Ray S, Prickett T, Hill V, Robbins PF, Goff SL, Rosenberg SA, Zacharakis N.   +14 more
europepmc   +1 more source

What is new on the horizon for the biologics world: New kids of the block - WAO state of art. [PDF]

World Allergy Organ J
Canonica GW, Ortega-Martell JA, Villarreal-González RV, Ansotegui IJ, Bachert C, Bernstein J, Bleecker E, Bondi B, Caminati M, Carr T, Cianferoni A, González ID, Díaz SG, Gómez RM, Hanania N, Heffler E, Nair P, Öztop N, Park HS, Pitè H, Rouadi P, Saito H, Triggiani M, Varricchi G, Virchow C, Yamada Y, Yáñez A, Morais-Almeida M.   +27 more
europepmc   +1 more source

The purinergic signaling interfaces in breast cancer angiogenesis. [PDF]

Purinergic Signal
da Silva FC, Stabile J, Fürstenau CR, Araújo TG.   +3 more
europepmc   +1 more source

<i>In ovo</i> carvacrol enriched inflammatory and T-cell transcriptional responses to <i>Escherichia coli</i> LPS in broiler chickens. [PDF]

Front Immunol
Meijer MMY, van den Brand H, Niknafs S, Roura E.   +3 more
europepmc   +1 more source

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Depletion of mouse alpha beta T cell antigen receptor bearing lymphocytes by neonatal monoclonal antibody treatment

The Journal of Immunology, 1991
Abstract Neonatal treatment with a monoclonal antibody specific for the alpha beta TCR results in mice with a long term, severe depletion in the number of alpha beta T cells in the periphery. Significant numbers of T cells reappear in the periphery about age 65 days, but these cells tend to lack expression of CD4 or CD8.
P F, Mixter, B C, Sydora, R M, Hershberg, M, Kronenberg   +3 more
openaire   +2 more sources

Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta+ and gamma delta+ human T cell clones isolated in IL-4.

The Journal of Immunology, 1989
Abstract IL-4 has been shown to act as a growth factor for human T cells. In addition, IL-4 can enhance CTL activity in MLC, but blocks IL-2 induced lymphokine activated killer cell activity in PBL. In our study, the cloning efficiencies, Ag-specific CTL activity and non-MHC-restricted cytotoxicity of CTL clones generated in IL-2 were ...
Paliard, X., Yssel, H., Blanchard, D., Waitz, J. A., deVries, J. E., Spits, H.   +5 more
openaire   +3 more sources