Results 231 to 240 of about 242,999 (280)

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

Nature, 1989
THE T-cell repertoire within an individual is biased to recognize antigen in the context of self major histocompatibility complex (MHC) antigens. This is thought to depend on a process of positive selection during development. Support for this notion has recently been obtained in experiments using transgenic mice bearing genes for T-cell receptors (TCR)
B, Scott, H, Blüthmann, H S, Teh, H, von Boehmer   +3 more
openaire   +2 more sources

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

The Journal of Immunology, 1991
Abstract We have characterized CD4-CD8- double negative (DN) thymocytes that express TCR-alpha beta and represent a minor thymocyte subpopulation expressing a markedly skewed TCR repertoire. We found that DN TCR-alpha beta + thymocytes resemble mature T cells in that they (a) are phenotypically CD2hiCD5hiQa2+HSA-, (b) appear late in ...
Y, Takahama, A, Kosugi, A, Singer
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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

Nature, 1988
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens ...
H S, Teh, P, Kisielow, B, Scott, H, Kishi, Y, Uematsu, H, Blüthmann, H, von Boehmer   +6 more
openaire   +2 more sources

Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8, and αβ T cell receptor molecules

International Immunology, 1990
We have been able to establish stable, minor histocompatibility antigen-specific, non-cytolytic, MHC-class II-restricted suppressor T cell clones and lines. These suppressor T cells rearrange, transcribe, and express alpha beta T cell receptor. An unusual feature of all our clones and lines is the co-expression of CD4 and CD8 molecules on their cell ...
Navreet K. Nanda, Elizabeth Thomson, Ivor Mason, E. Secarz   +3 more
openaire   +2 more sources

Alloantigen-specific cytotoxic clones bearing the alpha,beta T cell antigen receptor but not CD4 or CD8 molecules.

The Journal of Immunology, 1990
Abstract The vast majority of circulating lymphocytes that express the alpha,beta TCR in association with CD3 also express either CD4 or CD8 molecules, which are thought to act as important accessory structures in HLA class II- and I-restricted T cell functions, respectively.
A, Rivas, J, Koide, R, Laus, E G, Engleman   +3 more
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Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.

The Journal of Immunology, 1990
Abstract We have examined the expression of TCR genes in 4-hydroxy-3-nitrophenyl-acetyl (NP)-specific Ts cell hybridomas. Each of three independently isolated hybridomas expressed in-frame TCR alpha-chain rearrangements derived from the original suppressor Ts cell. Different V alpha and J alpha gene segments were rearranged and expressed
M, Collins, V K, Kuchroo, M J, Whitters, R M, O'Hara, K, Kelleher, R T, Kubo, M E, Dorf   +6 more
openaire   +2 more sources

Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex.

The Journal of Immunology, 1990
Abstract Eight different Ts cell hybridomas (including inducer (Ts1) and effector (Ts3) suppressor cells) specific for the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten were tested for their ability to respond to Ag or anti-CD3 antibody in a growth-inhibition assay. Results suggest that the expression of the TCR-CD3 complex on Ts hybridomas
V K, Kuchroo, P R, Billings, C, Levine, C A, Martin, R T, Kubo, M E, Dorf   +5 more
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Developmental regulation of αβ T cell antigen receptor assembly in immature CD4⁺CD8⁺ thymocytes

BioEssays, 1995
AbstractMost lymphocytes of the T cell lineage develop along the CD4/CD8 pathway and express antigen receptors on their surfaces consisting of clonotypic αβ chains associated with invariant CD3‐γδε components and ζ chains, collectively referred to as the T cell antigen receptor complex (TCR).
K P, Kearse, J P, Roberts, D L, Wiest, A, Singer   +3 more
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A Subset of Splenic Macrophages Process and Present Native Antigen to Naive Antigen-Specific CD4+T-Cells from Mice Transgenic for an αβ T-Cell Receptor

Cellular Immunology, 1995
The progeny of individual macrophage precursors from mouse spleen were examined for their ability to constitutively process and present native pigeon cytochrome c or a peptide fragment of this antigen to naive CD4+ T-cells from mice transgenic for a V alpha 11/V beta 3 TCR that recognizes an epitope in the antigen fragment.
D, Askew, J, Gatewood, E, Olivas, K, Havenith, W S, Walker   +4 more
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Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

Nature, 1987
The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex.
T, Saito, A, Weiss, J, Miller, M A, Norcross, R N, Germain   +4 more
openaire   +2 more sources