Results 131 to 140 of about 15,411,883 (261)

Targeting the Notch Signaling Pathway to Treat Atherosclerosis. [PDF]

Cells
Blagov A, Borodko D, Rozhkova U, Antonov S, Utkina A, Kovyanova T.   +5 more
europepmc   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source

Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells. [PDF]

Elife
Islam F, Williams C, Hogan T, Webb LV, Boal-Carvalho I, Seddon B.   +5 more
europepmc   +1 more source

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Aggregate, Volume 7, Issue 9, September 2026.
All‐D peptides that bind monomeric α‐synuclein shift the aggregation equilibrium, dismantle pathogenic fibrils, and suppress seeding activity in vitro and in cells. In a Parkinson's disease mouse model, treatment delays disease progression and extends survival, supporting direct aggregate disassembly as a disease‐modifying therapeutic strategy for ...
Sara Reithofer, Marc Sevenich, Madita Vollmer, Dila Kurtul, Laura Müller, Pelin Özdüzenciler, Laurin Gerhards, Kira Allmeroth, Mathias Wendt, Fahimeh Charbgoo, Sarah Schemmert, Marcel Naumann, Karolina Korostov, Gina Hartmann, Lothar Gremer, Gültekin Tamgüney, Dieter Willbold, Antje Willuweit   +17 more
wiley   +1 more source

Vitamin C enhances cytotoxicity of CAR-and εTRuC-engineered γδ T cells and modulates Ca²⁺, NFAT, NF-κB and ERK signaling in human γδ T cells. [PDF]

Front Immunol
Zarobkiewicz M, Ma L, Juraske C, Cierna L, Kouakanou L, Krißmer SM, Fiala GJ, Peters C, Schamel WW, Kabelitz D.   +9 more
europepmc   +1 more source

Extraction and Isolation of Bioactive Compounds From Malpighia glabra L. Leaves: In Vivo Investigation of the Leaf Extract Against Oxidative Stress and Inflammation Triggered by γ‐Radiation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Malpighia glabra L. leaves extract, enriched with flavonoids and β‐isoarborinol, exhibits antioxidant and anti‐inflammatory activities that moderate γ‐radiation‐induced systemic and tissue harm. The extract preserves intestinal, hepatic, renal, splenic, and systemic integrity by reducing oxidative stress and inflammation, supporting its potential as a ...
Amany M. Fekry, Walaa A. El‐Sabbagh, Marwa S. Abu Bakr, Abd El‐Salam I. Mohammed, Mona A. El‐Ghazaly   +4 more
wiley   +1 more source

From T cell engagers to next-generation immune cell engagers for cancer immunotherapy. [PDF]

Antib Ther
Yang Z, Fu YX.
europepmc   +1 more source

In Vitro Anti‐Inflammatory Activity of Sour Cherry (Prunus cerasus L.) Seed Oil and Computational Safety Profiling

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
In vitro anti‐inflammatory activity of sour cherry (Prunus cerasus L.) seed oil and computational safety profiling. ABSTRACT This study aimed to evaluate the in vitro anti‐inflammatory activity of sour cherry seed oils, including samples obtained by Soxhlet extraction and maceration, as well as ten commercial samples.
Tuğba Aydin, Tuğba Günbatan, Aysel Berkkan, Onur Kenan Ulutaş, Melike Sucu   +4 more
wiley   +1 more source

Bovine natural killer cell subsets can be defined by differential expression of CD161 (<i>KLRB1</i>). [PDF]

Front Immunol
Dry I, Kalandadze M, Wu Z, McGuinnes IC, Edmans MD, Benedictus L, Connelley T, Hope JC, Waddell LA.   +8 more
europepmc   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou, Guohang Shen, Lijing Si, Kaiyong Wang, Yang Chen, Ruoyan Wang, Yupei Dai   +6 more
wiley   +1 more source