Results 91 to 100 of about 54,159 (319)

Environmental pollutants-dependent molecular pathways and carcinogenesis [PDF]

BioDiscovery, 2019
Exposure to environmental pollutants can modulate many biological and molecular processes such as gene expression, gene repair mechanisms, hormone production and function and inflammation, resulting in adverse effects on human health including the ...
Myriam El Helou, Pascale A. Cohen, Mona Diab-Assaf, Sandra Ghayad   +3 more
doaj   +3 more sources

Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols [PDF]

, 2019
Organic aerosols generated from the smoldering combustion of wood critically impact air quality and health for billions of people worldwide; yet, the links between the chemical components and the optical or biological effects of woodsmoke aerosol (WSA ...
Denison, MS, He, G, Kam Chan, L, Karim, N, Nguyen, KQ, Nguyen, TB, Rice, RH, Yang, Y   +7 more
core  

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders [PDF]

, 2016
Cytochrome P450 (CYP) enzymes for which there is no functional information are considered "orphan" CYPs. Previous studies showed that CYP20A1, an orphan, is expressed in human hippocampus and substantia nigra, and in zebrafish (Danio rerio) CYP20A1 ...
Akira Kubota, Avadhani, Bairoch, Balasubramanian, Barnes, Benjamin Lemaire, Birnie, Boucher, Bryson, Cartharius, Chan, Cheng, Choudhary, Conor M. O'Meara, Coward, Dahlman-Wright, David C. Lamb, Flicek, Giguere, Goldstone, Gorelick, Grandjean, Gupta, Hassan, Honkakoski, Houck, Hulce, James-Zorn, Jared V. Goldstone, Jetten, John J. Stegeman, Jonsson, Jonsson, Kalaany, Kalueff, Krasowski, Krogh, Kubota, Kumar, Lamb, Livak, Maaswinkel, Maximino, Meling, Mitro, Morrison, Nakai, Nelson, Nelson, Otyepka, Petersen, Petersen, Ramos-Santana, Reschly, Robert L. Tanguay, Rost, Sezutsu, Stark, Stark, Strunnikova, Takiguchi, Thisse, Tomaszewska, Truong, Werck-Reichhart, Wirdefeldt, Xu, Yeh, Zhou   +68 more
core   +1 more source

Dopamine is an aryl hydrocarbon receptor agonist

Biochemical Journal, 2020
Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and ...
Hyejin Park, Un-ho Jin, Keshav Karki, Arul Jayaraman, Clint Allred, Sharon K. Michelhaugh, Sandeep Mittal, Robert S. Chapkin, Stephen Safe   +8 more
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Using nuclear receptor activity to stratify hepatocarcinogens. [PDF]

PLoS ONE, 2011
BackgroundNuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to ...
Imran Shah, Keith Houck, Richard S Judson, Robert J Kavlock, Matthew T Martin, David M Reif, John Wambaugh, David J Dix   +7 more
doaj   +1 more source

Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro [PDF]

, 2010
Endocrine disrupting chemicals have adverse effects on immune function that may result in respiratory conditions. Inhalation of dust is a major route of exposure to PBDEs; however, the impact of PBDEs on the immune response is unclear.
Hennigar, Stephen R
core   +1 more source

The microbiome and regulation of mucosal immunity [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106849/1/imm12231 ...
Abreu, Artis, Atarashi, Atarashi, Audie, Awane, Bailey, Bandeira, Bernink, Bohmig, Boismenu, Brandtzaeg, Buonocore, Burger-van Paassen, Butcher, Carol, Cash, Cavaglieri, Cepek, Cerutti, Chang, Chen, Cheroutre, Crabbe, Eyles, Ezendam, Farre, Forman, Forsythe, Frankel, Gewirtz, Hamada, Hisbergues, Hooper, Hooper, Ichinohe, Iimura, Ivanov, Ivanov, Iwasaki, Johansson, Karam, Kau, Kimura, Kleinschek, Kraehenbuhl, Lambrecht, Lee, Lorenz, Lorenz, Louis, Lycke, MacDonald, Macho Fernandez, Macpherson, Makita, Makita, Maslowski, Massacand, Matsuo, Mayer, Mazmanian, McDole, Millard, Moreau, Moretto, Munoz, Newberry, Niess, Noverr, Noverr, O'Hara, Okamoto, Ostman, Owen, Parr, Pickett, Pollard, Qiu, Resendiz-Albor, Rio, Rio, Round, Round, Saemann, Saemann, Satoh-Takayama, Shen, Simpson, Sipos, Southam, Spits, Sudo, Sun, Suzuki, Talham, Tien, Topping, Tsukahara, Turnbaugh, Umesaki, Vaishnava, Varol, Venkatraman, Vereecke, Wang, Wieland Brown, Wullt, Yang, Yen, Zelante, Zheng   +111 more
core   +1 more source

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source