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Combination of Chromatographic and Machine Learning-Driven Virtual Fractionation Identifies Aryl Hydrocarbon Receptor Agonists in Sediments. [PDF]

Environ Sci Technol
Wang H, Braun G, Kamjunke N, Krauss M, Jiang G, Escher BI.   +5 more
europepmc   +1 more source

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Aryl hydrocarbon receptor and colitis

Seminars in Immunopathology, 2013
The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large variety of natural and synthetic ligands, has recently become the object of great interest among researchers since it represents an important link between environment and immune-mediated pathologies.
MONTELEONE, IVAN, PALLONE, FRANCESCO, MONTELEONE, GIOVANNI   +2 more
openaire   +3 more sources

Sorafenib is an antagonist of the aryl hydrocarbon receptor

Toxicology, 2022
Sorafenib is an orally administered inhibitor of several tyrosine protein kinases. Treatment with sorafenib induces autophagy, which may suppress the growth of hepatocellular carcinoma (HCC) and other cancers. Aryl hydrocarbon receptor (AhR) is activated by xenbiotics and is involved in detoxification, but also plays other physiological roles.
Kuo-Liang Wei, Guan-Lun Gao, Yu-Ting Chou, Chih-Yi Lin, Shan-Chun Chen, Yi-Ling Chen, Hui Qin Choi, Chi-Chia Cheng, Jyan-Gwo Joseph Su   +8 more
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The aryl hydrocarbon receptor in immunity

Trends in Immunology, 2009
Low-molecular-weight chemicals or xenobiotics might contribute to the increasing prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR).
Charlotte, Esser, Agneta, Rannug, Brigitta, Stockinger   +2 more
openaire   +2 more sources

The aryl hydrocarbon receptor and light

Biological Chemistry, 2006
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we provide an overview of AhR activation by light with a focus on the role of tryptophan in light-induced AhR activation.
Agneta, Rannug, Ellen, Fritsche
openaire   +2 more sources

Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor

Journal of Biochemistry, 2000
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that acts in concert with the AhR nuclear translocator (ARNT), and alters gene expression in response to environmental contaminants such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD).
T, Ikuta, T, Tachibana, J, Watanabe, M, Yoshida, Y, Yoneda, K, Kawajiri   +5 more
openaire   +2 more sources

The Aryl Hydrocarbon Receptor Complex

Annual Review of Pharmacology and Toxicology, 1995
The heteromeric unliganded aryl hydrocarbon receptor complex (AHRC) contains the aryl hydrocarbon receptor monomer (AHR). Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC.
openaire   +2 more sources

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

Annual Review of Immunology, 2014
The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists.
Brigitta Stockinger, Paola Di Meglio, João H Duarte   +2 more
exaly   +3 more sources

Cyprodinil as an activator of aryl hydrocarbon receptor

Toxicology, 2013
Cyprodinil is a pyrimidinamine fungicide, used worldwide by agriculture. It is used to protect fruit plants and vegetables from a wide range of pathogens. Benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are toxic environmental pollutants and are prototypes of aryl hydrocarbon receptor (AHR) ligands.
Chien-Chung, Fang, Fei-Yun, Chen, Chang-Rong, Chen, Chien-Chiang, Liu, Liang-Chi, Wong, Yi-Wen, Liu, Jyan-Gwo Joseph, Su   +6 more
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Functions of the aryl hydrocarbon receptor in the skin

Seminars in Immunopathology, 2013
Among other functions, the skin serves as the barrier against the environment and provides vital protection from physical or chemical harm and from infection. Skin cells express the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor and sensor of environmental chemicals; at the same time, AHR ligands are abundant in skin from ...
Charlotte, Esser, Imke, Bargen, Heike, Weighardt, Thomas, Haarmann-Stemmann, Jean, Krutmann   +4 more
openaire   +2 more sources