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Role of aryl hydrocarbon receptor in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely expressed in a variety of animal species and humans. Recent animal and human data suggested that AHR is involved in various signaling pathways critical to cell normal ...
Shaolong, Feng +2 more
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Aryl hydrocarbon receptor and unexplained miscarriage
Journal of Obstetrics and Gynaecology Research, 2017AbstractAimThe aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage.MethodsThe expression of AhR mRNA and protein from decidua and villus were measured using real‐time reverse transcription–polymerase chain ...
Hongjie, Fan +3 more
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Trends in Endocrinology & Metabolism, 1994
The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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A snapshot of the aryl hydrocarbon receptor complex
Structure, 2023In this issue of Structure, Wen et al. present the cryo-EM structure of the aryl hydrocarbon receptor (AhR) and show how it is recruited and stabilized by the HSP90 molecular chaperone and its co-chaperones XAP2 and p23.
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The aryl hydrocarbon receptor: A comparative perspective
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1998The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor involved in the regulation of several genes, including those for xenobiotic-metabolizing enzymes such as cytochrome P450 1A and 1B forms. Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated ...
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Dexlansoprazole is an aryl hydrocarbon receptor agonist
Food and Chemical ToxicologyDexlansoprazole, a proton pump inhibitor, is commonly used to treat gastro-esophageal reflux disease and erosive esophagitis. The activated aryl hydrocarbon receptor (AhR) functions as a transcription factor by binding to the aryl hydrocarbon response element (AHRE) of its target genes, with cytochrome P450 (CYP) 1A1 being the most well-known target ...
Kuo-Liang Wei +6 more
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Auris Nasus Larynx, 2011
The aim of this study was to determine whether aryl hydrocarbon receptor (AhR) and AhR nuclear translocators (ARNTs) are expressed in human adenoid tissue.Paraffin-embedded human adenoid tissue specimens were obtained from eight children with adenoid hypertrophy.
Kazuhiko, Kubo +3 more
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The aim of this study was to determine whether aryl hydrocarbon receptor (AhR) and AhR nuclear translocators (ARNTs) are expressed in human adenoid tissue.Paraffin-embedded human adenoid tissue specimens were obtained from eight children with adenoid hypertrophy.
Kazuhiko, Kubo +3 more
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Biochemical Pharmacology, 1996
The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams +3 more
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The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams +3 more
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Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor
Journal of Natural Products, 2017The aryl hydrocarbon receptor (AhR) is a transcription factor activated by a vast array of natural and synthetic ligands. It plays a pivotal role in numerous physiological and pathological responses, such as cell proliferation and differentiation, induction of xenobiotic metabolizing enzymes, response to environmental toxins, and several others.
Gargaro, M +9 more
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Aryl hydrocarbon receptors: diversity and evolution
Chemico-Biological Interactions, 2002Animals have evolved inducible enzymatic defenses to facilitate the biotransformation and elimination of toxic compounds encountered in the environment. The sensory component of this system consists of soluble receptors that regulate the expression of certain isoforms of cytochrome P450, other enzymes, and transporters in response to environmental ...
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