Results 221 to 230 of about 34,222 (298)

Aryl hydrocarbon receptor in club cells drives Th17-mediated lung injury following inhalation exposure to environmentally persistent free radicals. [PDF]

Redox Biol
Pathak R, Kumar A, Ferrier A, Burk D, Cormier SA.   +4 more
europepmc   +1 more source

The multifaceted roles of the transcription factor SP1 in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract Alzheimer's disease (AD) is driven by interrelated pathologies, including the accumulation of amyloid β (Aβ), tau pathology, chronic neuroinflammation, and oxidative stress (OS). These pathological processes collectively lead to progressive neurodegeneration.
Zhengxiang Lv, Xiaodong Liu, Qin Huang, Haijun Liu, Zucai Xu, Ping Xu   +5 more
wiley   +1 more source

Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo. [PDF]

Toxicol Sci
Karchner SI, Aluru N, Franks DG, Mandl CA, Goldstone JV, Burke T, Champlin D, La Du JK, Perone DM, Stinson S, Truong L, Clark BW, Nacci D, Tanguay RL, Hahn ME.   +14 more
europepmc   +1 more source

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

VIEW, Volume 7, Issue 2, April 2026.
Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li, Nalan Tu, Xin Ning, Yunyan Cong, Fei Wu, Xiuli Zhang, Runrong Li, Yue Xu, Binqiao Wang, Liqin Jin, Yuanming Shen, Jihong Liu   +11 more
wiley   +1 more source

E-cigarette exposure impairs skeletal muscle mitochondrial function in male mice. [PDF]

Physiol Rep
Mazirka P, Choi J, Alvarez S, Jahuey P, O'Malley KA, Robinson ST, Scali ST, Ryan TE, Berceli SA, Kim K.   +9 more
europepmc   +1 more source

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 2, Page 228-242, April 2026.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source

Eco‐Evo‐Hydraulics: Integrating Fish Evolution Into Ecohydraulics for Conservation

Water Resources Research, Volume 62, Issue 4, April 2026.
Abstract Riverine fish conservation in eco‐hydraulics is often based on restoring or regulating river habitat to a semi‐natural state. For example, ecohydraulic projects support fish populations by increasing river connectivity through fishways, and by maintaining or restoring natural flow variance to enhance habitat quality and availability.
Xiatong Cai, Colin D. Rennie, Andrew P. Hendry, Simon Blanchet, Daniel I. Bolnick, Patrick Willems, Abdolmajid Mohammadian, Io S. Deflem, Bart Hellemans, Filip A. M. Volckaert, Joost A. M. Raeymaekers   +10 more
wiley   +1 more source

Targeting the Aryl Hydrocarbon Receptor: The Potential of Indole Compounds in the Treatment of Cystic Fibrosis. [PDF]

Int J Mol Sci
Hou S, Yue Q, Hou X, Wu Q.
europepmc   +1 more source

BMAL1 Drives Cisplatin Resistance in Non‐Small Cell Lung Cancer Via Lactate‐MRP1 Signaling Pathway

Thoracic Cancer, Volume 17, Issue 8, April 2026.
The drug cisplatin induces BMAL1 expression through AKT signaling in response to cisplatin‐induced oxidative stress. BMAL1 activates HIF‐1α‐mediated metabolic reprogramming and lactate production, which in turn activates the TAZ/c‐Jun/Snail complex to upregulate drug efflux pump MRP1, initiating and sustaining chemoresistance. ABSTRACT Lung cancer, the
Zixin Shi, Ziniu Qin, Chuantao Chen, Xiaolin Yang, Yunhan Hu, Xiaohui Meng, Yuxiang Cao, Xiang Tao, Zhijian Zhang, Tiancheng Xie, Huijun Wei, Zhihao Wu   +11 more
wiley   +1 more source