Results 231 to 240 of about 34,222 (298)

Activation of the aryl hydrocarbon receptor with structurally diverse ligands suppresses class switch to immunoglobulin A. [PDF]

BMC Res Notes
Costa AB, DeKrey GK.
europepmc   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Attempts to Achieve Targeted Covalent Inhibition of Hsp90β

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Electrophilic warheads were incorporated into Hsp90β‐selective inhibitors to covalently modify Lys58, which occupies the solvent‐exposed region of the binding pocket. Although many inhibitors display nanomolar affinity towards Hsp90β over a 24‐h period, analyses to determine covalent bond formation with this residue were inconclusive.
Terin D'Amico, Tyelor S. Reynolds, Michael A. Serwetnyk, Brian S. J. Blagg   +3 more
wiley   +1 more source

The gut-lung axis in COPD: immunomodulatory roles of gut microbiota and novel therapeutic strategies. [PDF]

Front Immunol
Ni FX, Wang HX, Hu J, Chen PS, Xu P, Chen HH, Jiang ZB, Huang DH.   +7 more
europepmc   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, Volume 293, Issue 8, Page 2393-2416, April 2026.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Ultraviolet radiation reshapes the metabolome of skin commensal bacteria, influencing AhR signaling and barrier function. [PDF]

Appl Environ Microbiol
Mercer SD, Elias A, Taylor G, Briggs GS, Bell M, McBain AJ, O'Neill CA.   +6 more
europepmc   +1 more source

Functions of AHR-1 and CYP-35A subfamily genes in caenorhabditis elegans [PDF]

Aarnio, Vuokko
core  

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

Journal of Clinical Periodontology, Volume 53, Issue 4, Page 644-655, April 2026.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng, Shiyuan Song, Wen Zhang, Dan Qiao, Min Wang, Zhifeng Wang, Jiajie Pu, Wenrong Yang, Fuhua Yan, Yangheng Zhang   +9 more
wiley   +1 more source

Dietary evaluation of Pleurotus ostreatus spent mushroom substrate on productivity, nutrient digestibility, egg quality, antioxidant status, and ovarian cytoprotective responses in laying hens. [PDF]

Poult Sci
Brouklogiannis I, Koutrotsios G, Zervakis GI, Mountzouris KC.   +3 more
europepmc   +1 more source

Impact of PAR2 on Tight Junctions and Esophageal Mucosal Inflammation in Rats with Gastroesophageal Reflux Disease

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
In GERD, elevated PAR2 expression impaired esophageal mucosal barrier function by downregulating and inducing the redistribution of Claudin‐1 and Claudin‐4, while promoting M1 macrophage‐mediated secretion of IL‐8 and IL‐1β. ABSTRACT Background Gastric content reflux activates protease‐activated receptor 2 (PAR2), which is a critical step in the ...
Mengdie Du, Luye Wang, Wenqian Duan, Wei Wang, Wenshang Fu, Yongshun Sun   +5 more
wiley   +1 more source