Results 1 to 10 of about 33,788 (287)
Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors [PDF]
Frontiers in Molecular Biosciences, 2021 Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti +7 more
doaj +3 more sources
Overview of Calcitonin Gene-Related Peptide and Its Receptor [PDF]
The Scientific World Journal, 2001 Calcitonin Gene-Related Peptide (CGRP), a 37 amino acid peptide identified as the alternately spliced gene product of calcitonin gene, is a sensory neuropeptide with potent cardiovascular effects. CGRP is distributed throughout the central and peripheral
Nambi Aiyar
doaj +2 more sources
A brief discussion on the role of calcitonin gene-related peptide in the efficacy of rehabilitation medicine [PDF]
Frontiers in Rehabilitation SciencesCalcitonin gene-related peptide (CGRP) is an active peptide composed of 37 amino acids that functions through specific receptors. It is widely distributed in small-diameter dorsal root ganglion neurons, trigeminal ganglion neurons, and nerve fibers ...
Guan Zhencheng, Xue Aiguo
doaj +2 more sources
Molecular Metabolism, 2021 Background: Therapies for metabolic diseases are numerous, yet improving insulin sensitivity beyond that induced by weight loss remains challenging. Therefore, search continues for novel treatment candidates that can stimulate insulin sensitivity and ...
Nina Sonne +2 more
doaj +1 more source
Multi-biological functions of intermedin in diseases
Frontiers in Physiology, 2023 Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily, and it is expressed extensively throughout the body.
Zhi Yang +9 more
doaj +1 more source
Calcitonin Gene-Related Peptide Receptor Agonism [PDF]
Circulation, 2017 Article, see p 367 Patients with heart failure experience high rates of hospitalization and death, combined with a poor quality of life. Current treatment is aimed at increasing cardiac contractility, enhancing vasodilation, and preventing maladaptive cardiac remodeling.
Danser, Jan +1 more
openaire +2 more sources
Frontiers in Pharmacology, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin +13 more
doaj +1 more source
The Journal of Headache and Pain, 2021 Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker +7 more
doaj +1 more source
Calcitonin gene‐related peptide receptors in human gastrointestinal epithelia [PDF]
British Journal of Pharmacology, 1994 The secretory responses to calcitonin gene‐related peptide (CGRP) receptor agonists have been characterized in two human adenocarcinoma cell lines, namely HCA‐7 and Colony‐29 (Col‐29) epithelia. These cells form polarized epithelial layers when grown on permeable supports and allow changes in electrogenic ion transport in response to agonists to be ...
H M, Cox, I R, Tough
openaire +2 more sources
Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension. [PDF]
PLoS ONE, 2015 Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic hypertensive patients, which increases their risk for brain damage. Although cerebral vascular smooth muscle cells express the potent vasodilatatory peptides calcitonin ...
Zhenghui Wang +6 more
doaj +1 more source