Results 191 to 200 of about 25,784 (209)

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2007
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).
Anthony B, Pinkerton, Dehua, Huang, Rowena V, Cube, John H, Hutchinson, Mary, Struthers, Julia M, Ayala, Pasquale P, Vicario, Sima R, Patel, Thomas, Wisniewski, Julie A, DeMartino, Jean-Michel, Vernier   +10 more
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The CCR2 receptor as a therapeutic target

Expert Opinion on Therapeutic Patents, 2005
The strict control of cell recruitment during the physiological inflammatory response fails in autoimmune inflammatory diseases. The chemokine system is a complex and redundant network of small soluble proteins and G-protein-coupled cell surface receptors that participate in the inflammatory response, mainly attracting cells to the inflammatory foci ...
Manuel Feria, Federico Díaz-González
openaire   +1 more source

Implication of CCR2 Chemokine Receptor in Cocaine-Induced Sensitization

Journal of Molecular Neuroscience, 2011
Cocaine-induced sensitization induces long-term neuroplastic changes in the striatum. Among these, extracellular signal-regulated kinase (ERK) is a fundamental component in striatal gene and epigenetic regulation and plays an important role in reward processes. As previous studies suggested that the chemokine CCL2 enhanced striatal dopamine release and
Trocello, Jean Marc, Rostène, William, Melik-Parsadaniantz, Stéphane, Godefroy, David, Roze, Emmanuel, Kitabgi, Patrick, Kuziel, William, Chalon, Sylvie, Caboche, Jocelyne, Apartis, Emmanuelle   +9 more
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CCR2: A characteristic chemokine receptor in normal and pathological intestine

Cytokine, 2023
C-C motif chemokine receptor 2 (CCR2), together with its ligands, especially C-C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in vivo environment. Scientometric methods are used to analyze intestine-related CCR2 expression.
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Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

Clinical Science, 2017
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16−CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes ...
Carolina N, França, Maria C O, Izar, Marinella N S, Hortêncio, Jônatas B, do Amaral, Carlos E S, Ferreira, Izabela D, Tuleta, Francisco A H, Fonseca   +6 more
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Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis

European Journal of Neurology, 2004
The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2–CCR2 axis are scarce in MS.
Sørensen, Torben Lykke, Ransohoff, R M, Strieter, R M, Sellebjerg, F   +3 more
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Novel, Orally Bioavailable γ-Aminoamide CC Chemokine Receptor 2 (CCR2) Antagonists

Journal of Medicinal Chemistry, 2006
Through modification of a screening hit we have discovered a structurally distinct new lead, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide (11), which has subsequently served as the departure point for an ongoing program targeting CCR2 antagonists.
Alexander, Pasternak, Dominick, Marino, Pasquale P, Vicario, Julia Marie, Ayala, Margaret A, Cascierri, William, Parsons, Sander G, Mills, Malcolm, Maccoss, Lihu, Yang   +8 more
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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

Archives of Pharmacal Research, 2013
Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis

International Journal of Molecular Medicine, 2003
The aim of this study was to examine the association of human autoimmune myasthenia gravis (MG) with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64I. CCR2 and CCR5 interact primarily with the human CC family ligands CCL2 (formerly called monocyte chemoattractant protein; MCP-1), CCL3 and CCL4 (macrophage inflammatory protein-
Xiaoyan, Zhao, Baback, Gharizadeh, Peter, Hjelmström, Ritva, Pirskanen, Pål, Nyrén, Ann-Kari, Lefvert, Mehran, Ghaderi   +6 more
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Molecular Modeling of Human CCR2 Receptor within POPC Lipid Bilayer

Structural Chemistry, 2016
Chemokine receptor 2 (CCR2), a G-protein coupled receptor (GPCR), is a critical target for several inflammatory and autoimmune diseases. The main restriction on designing desirable antagonists against CCR2 is the lack of appropriate crystal structure for this target.
Ahmad Ebadi, Dara Dastan, Mojtaba Azami, Adibe Karimi, Nima Razzaghi-Asl   +4 more
openaire   +1 more source