Results 201 to 209 of about 25,784 (209)

CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 in inflammation

2023
The CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 (iCCRs) play a critical role in orchestrating the recruitment of leukocytes to inflamed areas. However, excessive leukocyte accumulation during inflammation can cause tissue damage and various inflammatory disorders, making iCCRs a promising target for therapeutic interventions.
openaire   +2 more sources

Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

Bioorganic & Medicinal Chemistry Letters, 2009
A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification of two distinct substitution patterns about the cyclohexane ring as potent and selective CCR2 antagonists.
Robert J, Cherney, John B, Brogan, Ruowei, Mo, Yvonne C, Lo, Gengjie, Yang, Persymphonie B, Miller, Peggy A, Scherle, Bruce F, Molino, Percy H, Carter, Carl P, Decicco   +9 more
openaire   +2 more sources

CCR2 Chemokine Receptor

2007
Masaru Yamamoto, Tsuneya Ikezu
openaire   +1 more source

Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization

Letters in Drug Design & Discovery, 2007
O. Dasse, J. Evans, H.-X. Zhai, D. Zou, J. Kintigh, F. Chan, K. Hamilton, E. Hill, J. Eckman, P. Higgins, A. Volosov, P. Collart, J.-M. Nicolas, R.K. Kondru, C.E. Schwartz   +14 more
openaire   +1 more source

Novel, Acidic CCR2 Receptor Antagonists: From Hit to Lead

Letters in Drug Design & Discovery, 2007
D. Zou, H.-X. Zhai, J. Eckman, P. Higgins, M. Gillard, L. Knerr, S. Carre, P. Pasau, P. Collart, J. Grassi   +9 more
openaire   +1 more source

Association of the CCR2 Chemokine Receptor Gene Polymorphism with Myocardial Infarction

Doklady Biological Sciences, 2002
M I, Voevoda, S N, Ustinov, N S, Yudin, M M, Dolgikh, T N, Kuznetsova, V N, Maksimov, I V, Kulikov, A A, Gromov, A V, Shabalin, E V, Semaeva, V F, Kobzev, S R, Baum, V V, Gafarov, S K, Malyutina, A G, Romaschenko, YuP, Nikitin   +15 more
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Characterisation of Chemokine Receptor CCR1 and CCR2 Signalling in Monocytes

A central aspect of inflammatory diseases is the influx of leukocytes into the affected site. Chemokine and their receptors are key regulator of leukocyte recruitment. Given the complexity of the chemokine-receptor network, characterising it is critical for therapeutic interventions.
openaire   +1 more source

DIRECT EFFECT OF CCR2 RECEPTOR ON FOLLICLE ACTIVATION

Fertility and Sterility
Yamila Gamaleri, Delfina Ferman, Alison Ting, Eduardo Raul Dascal, Alejandro Lomniczi, Juan Pablo Pablo Jaworski, Marina C. Peluffo   +6 more
openaire   +1 more source

Chemokine receptor 2 (CCR2) mediates persistent sickle cell disease pain

The Journal of Pain, 2018
K. Sadler, K. Zappia, A. Weyer, C. O'Hara, C. Hillery, C. Stucky   +5 more
openaire   +1 more source