Results 201 to 210 of about 43,606 (294)

Mass Cytometry Workflow to Achieve High‐Dimensional Immunophenotyping in Resource‐Limited or Decentralized Environments

Current Protocols, Volume 6, Issue 3, March 2026.
Abstract Globally, regional and remote communities are burdened by both an increased prevalence and worse prognosis of many infectious and chronic diseases. However, largely owing to logistical challenges, these communities are under‐represented in clinical trials and research studies.
Natalie Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas de St Groth, Helen McGuire   +13 more
wiley   +1 more source

Single‐Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mice with natural microbiota show expected ageing spleen trends: naïve T cell loss with effector‐memory expansion, mature B cell shifts, Gzmk+ CD8+ T cell heterogeneity, diminished NK cytotoxicity and pro‐inflammatory macrophages. Chronic stress modestly counteracted these age‐related changes.
Chinna Susan Philip, Igor Filippov, Uku Haljasorg, Pärt Peterson   +3 more
wiley   +1 more source

Rewiring tumor-associated macrophages in hepatocellular carcinoma. [PDF]

Front Immunol
Han X, Jin R.
europepmc   +1 more source

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells

MedComm, Volume 7, Issue 3, March 2026.
HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosterone levels by desensitization of GnRHR, the downregulation of hTERT expression and telomerase activity, and the enhancement of Anticancer immunity.
Jae Hyeon Park, Joo Chan Lee, Swati Sharma, Chunxue Jiang, Haeun Lee, Hyun‐Ju Park, Hyung Sik Kim   +6 more
wiley   +1 more source

Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk. [PDF]

Front Immunol
Komaravolu RK, Chatterjee N, Kumar S, Allen JL, Durant C, Wu R, Valentin-Guillama G, McSkimming C, Drago F, Taylor AM, Miller YI, Ley K, McNamara CA, Alimadadi A, Hedrick CC.   +14 more
europepmc   +1 more source

Immunotherapy in Advanced Gastric Cancer: Advancing Precision Medicine and Emerging Therapeutic Strategies

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
Immunotherapy has evolved into a pivotal therapeutic approach for advanced gastric cancer, encompassing immune checkpoint inhibitors as monotherapy, as well as combination strategies with chemotherapy, targeted therapy, and dual‐specific checkpoint antibodies.
Li Zhang, Qihua Zhang, Xueliang Zhang, Aihong Mao, Yuhua Liu, Huiyan Luo   +5 more
wiley   +1 more source

CCR2/CXCR6 enhances tumor infiltration and antitumor efficacy of MSLN CAR-T cells. [PDF]

Cell Mol Life Sci
Zhang Y, Zhao L, Liu J, Yang X, Chen T, Chen Z, Li W, Hu Z, Pan F, Chen J, He L, Guo Z.   +11 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Macrophage Efferocytosis in Heart. [PDF]

Arterioscler Thromb Vasc Biol
Inui H, Yu X, Pfrender E, Bednarek J, Zhang L, Thorp EB.   +5 more
europepmc   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source