Results 81 to 90 of about 43,606 (294)

Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors

Molecular Pain, 2007
Background Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropathies ...
Monahan Patrick E, Li Baolin, Hamdouchi Chafiq, Lineswala Jayana, Henry Kenneth J, Miller Richard J, Ren Dongjun, Bhangoo Sonia, Chan David M, Ripsch Matthew S, White Fletcher A   +10 more
doaj   +1 more source

Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/Treponema pallidum Coinfection

Frontiers in Medicine, 2020
HIV-1/Treponema pallidum (T. pallidum) coinfection has become a global challenge, and three monocyte subsets express varying levels of the chemokine receptors CCR2 and CX3CR1.
Na Guo, Na Guo, Yongchang Chen, Yongchang Chen, Bin Su, Bin Su, Xiaodong Yang, Xiaodong Yang, Qiuyue Zhang, Qiuyue Zhang, Ting Song, Ting Song, Hao Wu, Hao Wu, Cuie Liu, Cuie Liu, Lifeng Liu, Lifeng Liu, Tong Zhang, Tong Zhang   +19 more
doaj   +1 more source

Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. [PDF]

PLoS ONE, 2014
Dendritic cells (DCs) play essential roles in both innate and adaptive immune responses. In addition, mutual regulation of the nervous system and immune system is well studied.
Norihisa Mikami, Kaori Sueda, Yusuke Ogitani, Ippei Otani, Miku Takatsuji, Yasuko Wada, Keiko Watanabe, Rintaro Yoshikawa, Satoshi Nishioka, Nagisa Hashimoto, Yayoi Miyagi, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa   +13 more
doaj   +1 more source

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. [PDF]

, 2019
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Coskun, Ayse K, Deeks, Steven, Gonzalo-Gil, Elena, Ikediobi, Uchenna, Lampkin, Teagan D, Leibowitz, Rebecca, Marconi, Vincent C, Mehta, Sameet, Porterfield, J Zachary, Rapuano, Patrick B, Rimland, David, Sutton, Richard E, Walker, Bruce D   +12 more
core  

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources

Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice [PDF]

The Journal of Immunology, 2001
AbstractThe chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages and T cells. To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans, we have generated mAbs against murine CCR2 and CCR5. In mice CCR2
M, Mack, J, Cihak, C, Simonis, B, Luckow, A E, Proudfoot, J, Plachý , H, Brühl, M, Frink, H J, Anders, V, Vielhauer, J, Pfirstinger, M, Stangassinger, D, Schlöndorff   +12 more
openaire   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. [PDF]

PLoS ONE, 2014
The chemokine receptors CX3CR1 and CCR2 have been implicated in the development of age-related macular degeneration (AMD). The evidence is mainly derived from experimental cell studies and murine models of AMD.
Mads Krüger Falk, Amardeep Singh, Carsten Faber, Mogens Holst Nissen, Thomas Hviid, Torben Lykke Sørensen   +5 more
doaj   +1 more source

Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists [PDF]

The Journal of Antibiotics, 2005
The chemokine receptor, CCR2, is predominantly expressed on monocytes/macrophages, and on a subset of memory T cells. It binds to several CC type chemokines of the monocyte chemoattractant protein (MCP) family of which MCP-1 exhibits the highest affinity.
Kithsiri B, Herath, Hiranthi, Jayasuriya, John G, Ondeyka, Jon D, Polishook, Gerald F, Bills, Anne W, Dombrowski, Angeles, Cabello, Pasquale P, Vicario, Hans, Zweerink, Ziqiang, Guan, Sheo B, Singh   +10 more
openaire   +2 more sources

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source