Results 1 to 10 of about 170,222 (245)
Viral Chemokine Receptors [PDF]
Frontiers in Immunology, 2015 When my lab sequenced the first chemokine receptors CXCR2 and CCR1 in 1991, the top BLAST hit for CCR1 was open reading frame (ORF) US28 of human cytomegalovirus (HCMV), indicating an obvious common ancestor and a possible example of gene piracy. Pox virologists had already identified virally encoded TNF and IFN-γ binding proteins, copied from the host
Philip eMurphy
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PET Imaging Radiotracers of Chemokine Receptors
Molecules, 2021 Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells.
Santosh R. Alluri +2 more
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Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
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Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
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Chemokines and chemokine receptors: A new strategy for breast cancer therapy
Cancer Medicine, 2020 Chemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development.
Hui Liu +8 more
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Chemokine Receptors and Phagocyte Biology in Zebrafish
Frontiers in Immunology, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer +2 more
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Nuclear Factor-Kappa B Regulation of Osteoclastogenesis and Osteoblastogenesis [PDF]
Endocrinology and Metabolism, 2023 Maintenance of skeletal integrity requires the coordinated activity of multinucleated bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts form resorption lacunae on bone surfaces in response to cytokines by fusion of precursor cells ...
Brendan F. Boyce +3 more
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The Role of Atypical Chemokine Receptor CCXCKR (CCRL1) in Human Diseases [PDF]
International Journal of Basic Science in Medicine, 2016 The role of chemokines and their receptors have been identified in many biological activities such as immune response and angiogenesis; however, their regulatory ways are under investigation.
Parvin Salimi, Abolghasem Esmaeili
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STAR Protocols, 2023 Summary: Chemokine receptors, a subfamily of G-protein-coupled receptors (GPCRs), are responsible for cell migration during physiological processes as well as in diseases like inflammation and cancers.
Siyi Gu, Mian Huang, Tracy M. Handel
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