Results 91 to 100 of about 275,691 (287)

Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. [PDF]

, 2017
Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to ...
Alexeev, Vitali, Fortuna, Giulio, Igoucheva, Olga, Mukhtarzada, Lila, Palisson, Francis, Salas-Alanis, Julio Cesar, South, Andrew P., Uitto, Jouni   +7 more
core   +1 more source

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy

Frontiers in Immunology, 2020
The anti-tumor activities of some members of the chemokine family are often overcome by the functions of many chemokines that are strongly and causatively linked with increased tumor progression.
Dina Morein, Nofar Erlichman, Adit Ben-Baruch   +2 more
doaj   +1 more source

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. [PDF]

, 2001
An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it
Lane, TE, Liu, MT
core  

TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]

, 2019
OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
core   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis

Cells
Tegumentary leishmaniasis (TL) presents two main clinical forms: cutaneous (CL) and mucosal (ML) leishmaniasis affecting skin and nasopharyngeal mucosa.
Julia Pimentel, M. Fernanda García Bustos, Paula Ragone, Jorge D. Marco, Paola Barroso, Andrea Cecilia Mesías, Mercedes Basombrío, María Occhionero, Federico Ramos, Susana Adriana Laucella, Cecilia Pérez Brandán, Cecilia Parodi   +11 more
doaj   +1 more source