Results 121 to 130 of about 185,430 (311)

Role of chemokine receptors in allergic diseases

, 2016
Immune cell trafficking is orchestrated by a family of small proteins named chemokines and leucocytes express chemokine receptors on their surface. Once chemokines are attached to these receptors, they trigger transendothelial migration.
Bouchaud, Grégory, A. Magnan, Castan, Laure, G. Bouchaud, L. Castan, Magnan, A.   +5 more
core   +1 more source

Viral Chemokine Receptors

Frontiers in Immunology, 2015
Philip eMurphy
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Atypical chemokine receptors in cancer : Friends or foes?

, 2016
The chemokine system is a fundamental component of cancer-related inflammation involved in all stages of cancer development. It controls not only leukocyte infiltration in primary tumors but also angiogenesis, cancer cell proliferation, and migration to ...
A. Mantovani, M. Massara, O. Bonavita, M. Locati, R. Bonecchi   +4 more
core   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Chemokine receptors in allergic diseases

, 2016
Under homeostatic conditions, as well as in various diseases, leukocyte migration is a crucial issue for the immune system that is mainly organized through the activation of bone marrow-derived cells in various tissues.
Bouchaud, Grégory, A. Magnan, Castan, Laure, G. Bouchaud, L. Castan, Magnan, A.   +5 more
core   +1 more source

The relationship between chemokines and breast cancer

Zhongguo aizheng zazhi, 2013
Many chemokines and chemokine receptors, such as CCL2 and CXCR4, participate in the growth, angiogenesis, distal metastasis of breast cancer. However, the recent failures in the clinical trials of some single target antagonists suggest that chemokine ...
欧周罗
doaj  

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Functional role of the CXCR4 chemokine receptor in thyroid cancer

, 2009
Thyroid cancer is the most common endocrine malignancy and its incidence is increasing worldwide. We previously found that normal rat thyroid cells, transduced with papillary thyroid cancer (PTC)-related oncogenes, display an inflammatory signature, that
Avilla, Elvira
core  

Chemokine receptors in GtoPdb v.2025.3

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [460, 459, 32, 125]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically possessing ...
Nomiyama, Hisayuki, Yoshie, Osamu, Luster, Andrew D., Power, Christine A., Proudfoot , Amanda E. I., Oppenheim, Joost J., Rot, Antal, Ben-Baruch, Adit, Locati, Massimo, Matsushima, Kouji, Murphy, Philip M., Graham, Gerard J., Burkhardt, Amanda M., Hills, Rebecca, Rosenkilde, Mette M., Sparre-Ulrich, Alexander H., Combadiere, Christophe, Bachelerie, Francoise, Nibbs, Robert J. B., Uddin, Mohib, Monaghan, Amy E., Farber, Joshua M., Sozzani, Silvano, Mantovani, Alberto, Förster, Reinhold, Moschovakis, Georgios L., Charo, Israel F., Zlotnik, Albert, Thelen, Marcus, Horuk, Richard   +29 more
core   +1 more source